Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function.
| Title: | Early renal and vascular changes in ADPKD patients with low-grade albumin excretion and normal renal function. |
|---|---|
| Authors: | Azurmendi PJ; Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina pazurmendi@lanari.fmed.uba.ar; Fraga AR; Galan FM; Kotliar C; Arrizurieta EE; Valdez MG; Forcada PJ; Stefan JS; Martin RS |
| Source: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2009 Aug; Vol. 24 (8), pp. 2458-63. Date of Electronic Publication: 2009 Mar 30. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Oxford University Press; Original Publication: [Berlin ; New York, NY] : Springer International, [c1986- |
| MeSH Terms: | Vasodilation*; Albuminuria/*metabolism ; Brachial Artery/*physiopathology ; Kidney/*metabolism ; Polycystic Kidney, Autosomal Dominant/*urine; Chemokine CCL2/blood ; Creatinine/blood ; Creatinine/urine ; Polycystic Kidney, Autosomal Dominant/blood ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Pulse |
| Abstract: | Background: Autosomal dominant polycystic kidney disease (ADPKD) shows an increase in both urine monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (CIMT) before changes in serum creatinine concentration. Although microalbuminuria is an index of disease progression, data on whether renal alterations and vascular remodelling are already present at normal or minimally increased levels of urine albumin excretion in early stages of the disease are lacking.; Methods: Forty-eight ADPKD patients (24.8 +/- 0.8 years) with normal renal function (MDRD 108.1 +/- 3.1 ml/min) and 21 age-matched controls were studied in a cross-sectional study. The urine albumin/creatinine ratio (UACR) above the upper range of controls (6.8 mg/g) was taken as the predictor of renal alterations and vascular remodelling. Urine MCP-1, MCP-1 fractional excretion (FE(MCP-1)), endothelial-dependent vascular relaxation (EDVR), aortic pulse-wave velocity (Ao-PWV) and CIMT were chosen as biological markers.; Results: No differences between ADPKD with UACR 6.8 mg/g showed values that were different from the two other groups. In addition, patients with UACR >6.8 and |
| Substance Nomenclature: | 0 (Chemokine CCL2); AYI8EX34EU (Creatinine) |
| Entry Date(s): | Date Created: 20090401 Date Completed: 20091022 Latest Revision: 20220316 |
| Update Code: | 20260130 |
| DOI: | 10.1093/ndt/gfp136 |
| PMID: | 19332866 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't