| Title: |
Rice bran oil ameliorates the symptoms of benign prostatic hyperplasia in male Wistar rats. |
| Authors: |
Miah, Md Ashik; Sathi, Mafuja Akter; Hasib, Md Golam; Rahman, Muktadiur; Mahmud, Nabila; Shill, Manik Chandra; Reza, Hasan Mahmud; Hossain, Murad; Rahman, Muhammed Mahfuzur; Mostaid, Md Shaki |
| Source: |
Avicenna Journal of Phytomedicine; May/Jun2026, Vol. 16 Issue 3, p458-472, 15p |
| Subject Terms: |
Benign prostatic hyperplasia; Rice oil; Anti-inflammatory agents; Antioxidants; Prostate-specific antigen; Laboratory rats; Oxidative stress; Anabolic steroids |
| Abstract: |
Objective: Benign prostatic hyperplasia (BPH) is the proliferation of prostatic cells and the growth of the prostate gland in elderly men. Oils that are rich in free fatty acids have been reported to be potentially effective in treating BPH. In the present study, we investigated the effect of rice bran oil (RO) on the treatment of testosterone enanthate (TE)-induced experimental BPH in male Wistar rats. Materials and Methods: An animal model of BPH was established by subcutaneous administration of TE to Wistar rats for 28 days. RO was administered by oral gavage daily before TE/corn oil injection at a dose of 400 and 800 mg/kg body weight. All the rats were sacrificed at the end of the experiment and we measured prostate index (PI), histological changes, and activities of antioxidant enzymes. Moreover, we assessed the level of prostate-specific antigen (PSA) in the serum. Results: Our findings indicate that RO significantly inhibited the development of BPH in experimental rats, reduced PI (p |
| : |
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| Database: |
Complementary Index |