Cerebral arteriovenous malformations at 3.0 T: intraindividual comparative study of 4D-MRA in combination with selective arterial spin labeling and digital subtraction angiography.
| Title: | Cerebral arteriovenous malformations at 3.0 T: intraindividual comparative study of 4D-MRA in combination with selective arterial spin labeling and digital subtraction angiography. |
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| Authors: | Kukuk GM; Department of Radiology, University of Bonn, Bonn, Germany. Guido.Kukuk@ukb.uni-bonn.de; Hadizadeh DR; Boström A; Gieseke J; Bergener J; Nelles M; Mürtz P; Urbach H; Schild HH; Willinek WA |
| Source: | Investigative radiology [Invest Radiol] 2010 Mar; Vol. 45 (3), pp. 126-32. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0045377 Publication Model: Print Cited Medium: Internet ISSN: 1536-0210 (Electronic) Linking ISSN: 00209996 NLM ISO Abbreviation: Invest Radiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins; Original Publication: Philadelphia. |
| MeSH Terms: | Angiography, Digital Subtraction/*methods ; Intracranial Arteriovenous Malformations/*diagnosis ; Magnetic Resonance Angiography/*methods; Intracranial Arteriovenous Malformations/diagnostic imaging ; Adolescent ; Adult ; Contrast Media ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Male ; Middle Aged ; Organometallic Compounds ; Prospective Studies ; Spin Labels |
| Abstract: | Objective: Prospective intraindividual comparison of 4-dimensional contrast-enhanced MR angiography (4D-MRA) in combination with selective arterial spin labeling (ASL) at 3.0 Tesla and digital subtraction angiography (DSA) for anatomic and functional characterization of cerebral arteriovenous malformations (AVMs).; Materials and Methods: In a prospective intraindividual comparative study, 16 patients diagnosed with symptomatic cerebral AVMs underwent 4D-MRA at an isotropic spatial resolution of 1.1 x 1.1 x 1.1 mm and a temporal resolution of 572 milliseconds, regional brain perfusion imaging using selective ASL and DSA. Selective ASL was performed for selective labeling of both carotid arteries and the vertebrobasilar complex. In a stepwise approach, all images were evaluated by 2 radiologists according to technical success rate, Spetzler-Martin classification, identification of arterial feeders, and existence of anatomic variants or functional cross-filling.; Results: 4D-MRA allowed for the same Spetzler-Martin classification as DSA in all patients. Of 28, 26 (93%) feeding arteries were correctly identified by both readers using 4D-MRA alone. Selective ASL provided additional functional or anatomic information in 4 of 16 cases (25%), enabling the detection of a cross-filling feeding artery that was not identified by 4D-MRA without selective ASL, thus improving the sensitivity of MRI in identification of arterial feeders from 26/28 (93%) to 27/28 (96%). The additional functional information regarding anatomic variants and cross-filling provided by selective ASL was confirmed by DSA in all cases.; Conclusion: 4D-MRA in combination with selective arterial spin labeling is a promising tool for the noninvasive assessment of cerebral AVMs providing functional information that so far has been gained only with DSA. |
| Substance Nomenclature: | 0 (Contrast Media); 0 (Organometallic Compounds); 0 (Spin Labels); 1BJ477IO2L (gadobutrol) |
| Entry Date(s): | Date Created: 20100113 Date Completed: 20100518 Latest Revision: 20161125 |
| Update Code: | 20260130 |
| DOI: | 10.1097/RLI.0b013e3181c7bcfe |
| PMID: | 20065859 |
| Database: | MEDLINE |
Comparative Study; Journal Article