Intravascular ultrasound measures of coronary atherosclerosis are associated with the Framingham risk score: an analysis from a global IVUS registry.
| Title: | Intravascular ultrasound measures of coronary atherosclerosis are associated with the Framingham risk score: an analysis from a global IVUS registry. |
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| Authors: | Marso SP; Mid America Heart Institute, University of Missouri Kansas City, Kansas City, MO 64111, USA. smarso@saint-lukes.org; Frutkin AD; Mehta SK; House JA; McCrary JR; Klauss V; Lerman A; Leon MB; Nair A; Margolis P; Erbel R; Nasu K; Schiele F; Margolis J |
| Source: | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2009 Jun; Vol. 5 (2), pp. 212-8. |
| Publication Type: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Société Europa édition Country of Publication: France NLM ID: 101251040 Publication Model: Print Cited Medium: Internet ISSN: 1969-6213 (Electronic) Linking ISSN: 1774024X NLM ISO Abbreviation: EuroIntervention Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Toulouse : Société Europa édition, c2005- |
| MeSH Terms: | Health Status Indicators* ; Ultrasonography, Interventional*; Coronary Artery Disease/*diagnostic imaging; Aged ; Asia ; Chi-Square Distribution ; Coronary Angiography ; Disease Progression ; Europe ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Registries ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; United States |
| Abstract: | Aims: In addition to an adjunctive imaging platform during coronary angiography, intravascular ultrasound (IVUS) with Virtual Histology (VH) is increasingly being used to quantify coronary atherosclerosis. The relationship between VH-IVUS measures of coronary atherosclerosis and traditional cardiovascular risk factors has not been completely described. The objective of this study was to determine if an association exists between VH-IVUS measures of coronary atherosclerosis and the Framingham risk score in a prospective, multinational registry.; Methods and Results: Patients enrolled from 2004-2006 at 37 multinational centres in the prospective VHIVUS Global Registry were analysed. All subjects underwent diagnostic coronary angiography followed by IVUS. A Framingham risk score (FRS) was calculated for each subject, then stratified into three exclusive estimates (or= 20%) for future coronary heart disease (CHD) event risk over 10 years. Among 531 patients, plaque volume of the most diseased 10 mm segment increased with increasing FRS (P=0.006, adjusted for multiple comparisons). Patients with higher FRS estimates of CHD risk had a higher proportion of plaque classified as thin cap fibroatheroma compared with patients in the middle and lower risk score categories (21.4% vs 15.2% and 11.3%, respectively, P=0.008, adjusted for multiple comparisons).; Conclusions: Using data from a large, multinational VH-IVUS registry we describe an association between the Framingham risk score and VH-IVUS measures of atherosclerosis within the most diseased 10 mm segment, namely plaque volume and the proportion of thin cap fibroatheroma. |
| Entry Date(s): | Date Created: 20100511 Date Completed: 20100812 Latest Revision: 20260128 |
| Update Code: | 20260130 |
| DOI: | 10.4244/eijv5i2a33 |
| PMID: | 20449931 |
| Database: | MEDLINE |
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't