Persistent infections and their relationship with selected oncologic and non-tumor pathologies.
| Title: | Persistent infections and their relationship with selected oncologic and non-tumor pathologies. |
|---|---|
| Authors: | Chumak AA; S.I. Research Centre for Radiation Medicine, Kyiv, Ukraine. papatolia@mail.ru; Abramenko IV; Bilous NI; Filonenko IA; Kostin OV; Pleskach OY; Pleskach GV; Efremova N; Yanko J |
| Source: | Journal of immunotoxicology [J Immunotoxicol] 2010 Oct-Dec; Vol. 7 (4), pp. 279-88. Date of Electronic Publication: 2010 Jun 03. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101201960 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1547-6901 (Electronic) Linking ISSN: 1547691X NLM ISO Abbreviation: J Immunotoxicol Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare; Original Publication: Philadelphia, PA : Taylor & Francis Health Sciences, c2004- |
| MeSH Terms: | Acute Radiation Syndrome/*epidemiology ; Cytomegalovirus/*immunology ; Cytomegalovirus Infections/*epidemiology ; Hepacivirus/*immunology ; Hepatitis C, Chronic/*epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/*epidemiology; Acute Radiation Syndrome/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigens, Neoplasm/immunology ; Antigens, Viral/immunology ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/immunology ; Hepacivirus/pathogenicity ; Hepatitis C, Chronic/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Adult ; Chernobyl Nuclear Accident ; Cross Reactions ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence |
| Abstract: | Our earlier studies of hepatitis C virus (HCV) infection rates among blood donors at the Kyiv Municipal Blood Center revealed a 3.45% HCV+ prevalence in these "healthy" hosts. In the study here, we analyzed HCV (as well as cytomegalovirus [CMV]) prevalence among Chernobyl nuclear power plant (NPP) accident sufferers--cleanup workers, local residents, NPP workers, and convalescent patients--who suffered acute radiation syndrome (ARS) as a result of the 1986 accident, and individuals who had not been exposed to ionizing radiation (IR). Serological analyses of antibodies against each pathogen (via enzyme-linked immunosorbent assay [ELISA]) revealed the highest HCV (i.e., 27.2%) and CMV (85.6%) prevalence in the convalescent hosts. Though the HCV prevalence (reflecting a current/past infection) among the cleanup workers (and other groups) was lower (i.e., 11-25%), viral presence was "associated" with a higher incidence of selected somatic diseases, for example, thyroiditis, goiter, hypertension, Type 1 diabetes, chronic hepatitis/gastritis, in the cleanup workers. A similar scenario with respect to CMV was also seen, i.e., lower prevalence rates [relative to in ARS patients] and "association" between CMV status and incidence of chronic gastritis, arthritis, and bronchitis, in the cleanup workers and IR-non-exposed controls. Further, irrespective of CMV status, there was a clear delineation between incidence rate(s) of each of the pathologies and whether or not the person was/was not exposed in 1986. We also investigated, due to a high incidence of chronic lymphocytic leukemia (CLL) among Chernobyl sufferers, if there was homology between immunoglobulins (Igs) generated by these transformed cells and known antiviral and antimicrobial Igs. Polymerase chain reaction (PCR) analyses of Ig heavy-chain variable (IgHV) genes in cells from CLL patients who were/were not exposed in 1986 revealed a significant homology of some IgHV genes with Igs directed against infectious agents. However, no differences were found between the sequences from IR-exposed and IR-non-exposed CLL patients. Based on the findings here, we conclude that a past/ongoing presence of certain viral infections (i.e., CMV and/or HCV) in a host can modify (aggravate) the clinical course of certain somatic (i.e., non-tumor) diseases and promote malignancies (i.e., CLL), and that each of these outcomes could be modulated as a result of that host's past exposure to IR. |
| Substance Nomenclature: | 0 (Antibodies, Viral); 0 (Antigens, Neoplasm); 0 (Antigens, Viral) |
| Entry Date(s): | Date Created: 20100604 Date Completed: 20110627 Latest Revision: 20101118 |
| Update Code: | 20260130 |
| DOI: | 10.3109/1547691X.2010.489528 |
| PMID: | 20518708 |
| Database: | MEDLINE |
Journal Article