Maternal autoimmune thyroiditis and congenital malformations of newborns in a cohort of Slovak women.
| Title: | Maternal autoimmune thyroiditis and congenital malformations of newborns in a cohort of Slovak women. |
|---|---|
| Authors: | Vargová V; Pavol Jozef Šafárik University, Košice, Slovak Republic.; Pytliak M; Mechírová V; Felšöci M |
| Source: | Wiener medizinische Wochenschrift (1946) [Wien Med Wochenschr] 2010 Sep; Vol. 160 (17-18), pp. 470-4. Date of Electronic Publication: 2010 Aug 24. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Austria NLM ID: 8708475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-258X (Electronic) Linking ISSN: 00435341 NLM ISO Abbreviation: Wien Med Wochenschr Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : Wien : Springer Verlag; Original Publication: [Wien : Brüder Hollinek, 1946- |
| MeSH Terms: | Congenital Abnormalities/*epidemiology ; Pregnancy Complications/*epidemiology ; Thyroiditis, Autoimmune/*epidemiology; Autoantibodies/blood ; Congenital Abnormalities/diagnosis ; Hypothyroidism/diagnosis ; Hypothyroidism/epidemiology ; Iodide Peroxidase/immunology ; Pregnancy Complications/diagnosis ; Thyroiditis, Autoimmune/diagnosis ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Risk Factors ; Slovakia ; Thyroid Function Tests ; Ultrasonography, Prenatal |
| Abstract: | Background: Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM).; Methods: We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and comparison to birth proportions of newborns.; Results: The total volume of the thyroid gland and anti-TPO levels were significantly higher in mothers of the group with CM (p < 0.001 and p < 0.01, respectively). The birth weight and length were significantly lower in the group with congenital malformation when compared to controls (p < 0.0001 and p < 0.001, respectively).; Conclusions: Based on the results of our study, we suggest that thyroid diseases of a mother might participate in congenital malformations of their newborn, although no direct association between thyroid autoantibodies and congenital malformations has been described as of yet. |
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| Substance Nomenclature: | 0 (Autoantibodies); EC 1.11.1.8 (Iodide Peroxidase) |
| Entry Date(s): | Date Created: 20100826 Date Completed: 20110322 Latest Revision: 20211020 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10354-010-0824-z |
| PMID: | 20737223 |
| Database: | MEDLINE |
Journal Article