[Expansion of the functional domain of chicken alpha-globin genes].
| Title: | [Expansion of the functional domain of chicken alpha-globin genes]. |
|---|---|
| Authors: | Filonenko ES; Gavrilov AA; Razin SV; Iarovaia OV |
| Source: | Genetika [Genetika] 2010 Sep; Vol. 46 (9), pp. 1164-7. |
| Publication Type: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| Language: | Russian |
| Journal Info: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0047354 Publication Model: Print Cited Medium: Print ISSN: 0016-6758 (Print) Linking ISSN: 00166758 NLM ISO Abbreviation: Genetika Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Moskva : Izdatelstvo Nauka |
| MeSH Terms: | Avian Proteins/*genetics ; Chickens/*genetics ; alpha-Globins/*genetics; Avian Proteins/biosynthesis ; Chromatin/genetics ; Erythroblasts/metabolism ; Lymphoid Tissue/metabolism ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/genetics ; alpha-Globins/biosynthesis ; Animals ; CpG Islands ; Enhancer Elements, Genetic ; Humans ; Multigene Family |
| Abstract: | The transcriptional domain of chicken alpha-globin genes was shown to contain the non-globin coding erythroid-specific TMEM8 gene inducible upon terminal differentiation of erythroblasts. Acquirement by the chicken TMEM8 gene of the erythroid-specific expression correlates with its approachment to the cluster of alpha-globin genes as a result of inversion of a 170-kb chromosomal segment. The human TMEM8 gene is located far from the globin genes and is not expressed in erythroblasts. Transcription of the TMEM8 gene and adult globins in differentiated chicken erythroid cells is controlled by alternative activatory hubs sharing two regulatory elements (including the erythroid enhancer). A conclusion is made that in mature erythroblasts these regulatory elements shuttle between two different activatory hubs. |
| Substance Nomenclature: | 0 (Avian Proteins); 0 (Chromatin); 0 (Membrane Glycoproteins); 0 (TMEM8A protein, human); 0 (alpha-Globins) |
| Entry Date(s): | Date Created: 20101111 Date Completed: 20101203 Latest Revision: 20111010 |
| Update Code: | 20260130 |
| PMID: | 21061608 |
| Database: | MEDLINE |
English Abstract; Journal Article; Research Support, Non-U.S. Gov't