Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats.
| Title: | Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats. |
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| Authors: | Snoeren EM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands.; Bovens A; Refsgaard LK; Westphal KG; Waldinger MD; Olivier B; Oosting RS |
| Source: | The journal of sexual medicine [J Sex Med] 2011 Apr; Vol. 8 (4), pp. 989-1001. Date of Electronic Publication: 2011 Jan 14. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: Netherlands NLM ID: 101230693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-6109 (Electronic) Linking ISSN: 17436095 NLM ISO Abbreviation: J Sex Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : [Oxford] : Oxford University Press; Original Publication: Malden, MA : Blackwell Pub. |
| MeSH Terms: | Androgens/*pharmacology ; Imidazoles/*pharmacology ; Phosphodiesterase 5 Inhibitors/*pharmacology ; Piperazines/*pharmacology ; Sexual Behavior, Animal/*drug effects ; Testosterone/*pharmacology ; Vasodilator Agents/*pharmacology; Androgens/administration & dosage ; Imidazoles/administration & dosage ; Piperazines/administration & dosage ; Sexual Dysfunctions, Psychological/drug therapy ; Sulfones/administration & dosage ; Sulfones/pharmacology ; Testosterone/administration & dosage ; Triazines/administration & dosage ; Triazines/pharmacology ; Vasodilator Agents/administration & dosage ; Administration, Oral ; Analysis of Variance ; Animals ; Drug Combinations ; Female ; Ovariectomy ; Posture ; Rats ; Vardenafil Dihydrochloride |
| Abstract: | Introduction: Hypoactive sexual desire disorder (HSDD) is a common problem in women and may have a negative impact on quality of life. A recent clinical study shows an increase in sexual drive of HSDD women after cotreatment of testosterone and vardenafil (phosphodiesterase type 5 inhibitor).; Aim: In this study, we investigated the effect of testosterone and vardenafil on sexual activity in female rats.; Main Outcome Measures: Proceptive (darts and hops), receptive (lordosis), and paced-mating (percentages after exits and contact-return latencies) behaviors were quantified.; Methods: Ovariectomized female rats, sub-primed with only estradiol and fully primed with estradiol and progesterone, were tested in a paced-mating sex test and sexual behaviors were quantified. The sub-primed rats are thought to model HSDD. The effect of testosterone (100 and 300 µg, subcutaneous [SC]) and vardenafil (10 mg/kg, per os [PO]) alone and testosterone (300 µg, SC) in combination with vardenafil (3 and 10 mg/kg, PO) were tested. We also studied the effects of testosterone (300 µg, SC) + intracerebroventricular (ICV) injections of vardenafil (25 and 50 µg) on sexual activity.; Results: No effect of testosterone and vardenafil alone was found, but cotreatment of testosterone and vardenafil (PO) caused a significant increase in proceptive and receptive behavior in the sub-primed female rats. Testosterone and vardenafil did not affect fully primed females. ICV administration of vardenafil combined with systemic testosterone, on the other hand, had no effect on sexual activity in both sub-primed and fully primed female rats.; Conclusions: We conclude that cotreatment of subcutaneous testosterone and oral vardenafil increase sexual activity in sub-primed female rats. Our data supports the human finding that combination treatment of testosterone and vardenafil could be used as a new treatment for women with HSDD.; (© 2011 International Society for Sexual Medicine.) |
| Substance Nomenclature: | 0 (Androgens); 0 (Drug Combinations); 0 (Imidazoles); 0 (Phosphodiesterase 5 Inhibitors); 0 (Piperazines); 0 (Sulfones); 0 (Triazines); 0 (Vasodilator Agents); 3XMK78S47O (Testosterone); 5O8R96XMH7 (Vardenafil Dihydrochloride) |
| Entry Date(s): | Date Created: 20110118 Date Completed: 20110906 Latest Revision: 20151119 |
| Update Code: | 20260130 |
| DOI: | 10.1111/j.1743-6109.2010.02177.x |
| PMID: | 21235726 |
| Database: | MEDLINE |
Journal Article