Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents.
| Title: | Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents. |
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| Authors: | Amnerkar ND; Department of Medicinal Chemistry, Sharad Pawar College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India. nikhilamnerkar@gmail.com; Bhusari KP |
| Source: | Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2011 Feb; Vol. 26 (1), pp. 22-8. Date of Electronic Publication: 2011 Jan 21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basingstoke, UK : Taylor & Francis, c2002- |
| MeSH Terms: | Acetamides/*chemistry ; Anthelmintics/*pharmacology ; Anti-Bacterial Agents/*pharmacology ; Antifungal Agents/*pharmacology ; Fungi/*drug effects ; Gram-Negative Bacteria/*drug effects ; Gram-Positive Bacteria/*drug effects ; Oligochaeta/*drug effects ; Thiazoles/*chemistry; Anthelmintics/chemical synthesis ; Anti-Bacterial Agents/chemical synthesis ; Antifungal Agents/chemical synthesis ; Animals ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship |
| Abstract: | A series of 4-(6-substituted-1,3-benzothiazol-2-yl)amino-2-(4-substitutedphenyl)- amino-1,3-thiazoles, 9-24 have been synthesised from 2-chloro-N-(6-substituted-1,3-benzothiazol-2-yl)acetamides, 5-8. The structures of these compounds have been elucidated by spectral (IR, (1)H NMR, Mass) and elemental (C, H, N) analysis data. All the newly synthesised compounds (9-24) were screened for their antibacterial, antifungal and anthelmintic activities. Almost all of these compounds showed moderate to good antimicrobial activity against two gram negative bacteria (E. coli, P. aeruginosa), two gram positive bacteria (S. aureus, B. subtilis), pathogenic fungal strains (C. albicans, A. niger) and good anthelmintic activity against earthworm species (P. corethruses). Compounds 18 and 20 exhibited good antibacterial and antifungal activities, while compound 22 displayed the most significant anthelmintic activity. |
| Substance Nomenclature: | 0 (Acetamides); 0 (Anthelmintics); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Thiazoles) |
| Entry Date(s): | Date Created: 20110122 Date Completed: 20110802 Latest Revision: 20220321 |
| Update Code: | 20260130 |
| DOI: | 10.3109/14756360903555258 |
| PMID: | 21250821 |
| Database: | MEDLINE |
Journal Article