Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors.
| Title: | Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors. |
|---|---|
| Authors: | Zientara-Rytter K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.; Lukomska J; Moniuszko G; Gwozdecki R; Surowiecki P; Lewandowska M; Liszewska F; Wawrzyńska A; Sirko A |
| Source: | Autophagy [Autophagy] 2011 Oct; Vol. 7 (10), pp. 1145-58. Date of Electronic Publication: 2011 Oct 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Philadelphia, PA : Taylor & Francis; Original Publication: Georgetown, TX : Landes Bioscience, 2005- |
| MeSH Terms: | Autophagy* ; Gene Expression Regulation, Plant*; Adaptor Proteins, Signal Transducing/*metabolism ; Arabidopsis Proteins/*metabolism ; Carrier Proteins/*metabolism ; Microfilament Proteins/*metabolism ; Receptors, Cytoplasmic and Nuclear/*genetics ; Nicotiana/*metabolism; Cytoplasm/metabolism ; Microscopy, Fluorescence/methods ; Nitrogen/chemistry ; Plant Leaves/metabolism ; Receptors, Cytoplasmic and Nuclear/physiology ; Sulfur/chemistry ; Autophagy-Related Protein 8 Family ; Environment ; Humans ; Protein Structure, Tertiary ; Sequestosome-1 Protein |
| Abstract: | Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagy-lysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to nutrient deficiency, programmed cell death and innate immune response. In mammalian cells the selectivity of autophagy is ensured by the presence of cargo receptors, such as p62/SQSTM1 and NBR1, responsible for sequestration of the ubiquitinated proteins. In plants no selective cargo receptors have been identified yet. The present report indicates that structural and functional homologs of p62 and NBR1 proteins exist in plants. The tobacco protein, named Joka2, has been identified in yeast two-hybrid search as a binding partner of a small coiled-coil protein, a member of UP9/LSU family of unknown function, encoded by the UP9C gene strongly and specifically induced during sulfur deficiency. The typical domains of p62 and NBR1 are conserved in Joka2. Similarly to p62, Joka2-YFP has dual localization (cytosolic speckles and the nucleus); it forms homodimers and interacts with a member of the ATG8 family. Increased expression of Joka2 and ATG8f was observed in roots of tobacco plants grown for two days in nutrient-deficient conditions. Constitutive ectopic expression of Joka2-YFP in tobacco resulted in attenuated response (manifested by lesser yellowing of the leaves) to nutrient deficiency. In conclusion, Joka2, and presumably the process of selective autophagy, might constitute an important part of plant response to environmental stresses. |
| References: | Curr Opin Cell Biol. 2010 Apr;22(2):124-31. (PMID: 20034776); Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67. (PMID: 19491929); Plant J. 2005 May;42(4):598-608. (PMID: 15860017); FEBS Lett. 2010 Apr 2;584(7):1350-8. (PMID: 20079356); Genetics. 2008 Mar;178(3):1339-53. (PMID: 18245858); J Exp Bot. 2006;57(10):2173-82. (PMID: 16720610); Nat Cell Biol. 2010 Sep;12(9):836-41. (PMID: 20811356); EMBO Rep. 2007 Sep;8(9):864-70. (PMID: 17721444); J Biol Chem. 2002 Sep 6;277(36):33105-14. (PMID: 12070171); Mol Cell. 2009 Feb 27;33(4):505-16. (PMID: 19250911); J Exp Bot. 2008;59(14):4029-43. (PMID: 18836138); Curr Opin Cell Biol. 2010 Apr;22(2):192-8. (PMID: 19962293); Plant Cell Physiol. 2006 Dec;47(12):1641-52. (PMID: 17085765); Free Radic Biol Med. 2009 Feb 15;46(4):492-501. (PMID: 19071211); J Biol Chem. 2010 Jan 15;285(3):2077-89. (PMID: 19903815); Autophagy. 2010 Aug;6(6):784-93. (PMID: 20574168); Cell. 2010 May 14;141(4):656-67. (PMID: 20478256); Nat Cell Biol. 2009 Dec;11(12):1433-7. (PMID: 19898463); Immunol Rev. 2010 Jul;236:95-109. (PMID: 20636811); Plant Physiol. 2002 Jul;129(3):1181-93. (PMID: 12114572); Nucleic Acids Res. 1992 Feb 25;20(4):689-97. (PMID: 1542565); Nat Cell Biol. 2010 Mar;12(3):213-23. (PMID: 20173742); Cell Cycle. 2009 Jul 1;8(13):1986-90. (PMID: 19502794); Cell Signal. 2010 Oct;22(10):1576-96. (PMID: 20600853); Dokl Biochem Biophys. 2009 Sep-Oct;428:257-60. (PMID: 20848913); Cell. 2007 Dec 14;131(6):1149-63. (PMID: 18083104); Protoplasma. 2010 Dec;247(3-4):233-56. (PMID: 20734094); Semin Cell Dev Biol. 2009 Dec;20(9):1041-7. (PMID: 19406248); FEBS Lett. 2010 Apr 2;584(7):1393-8. (PMID: 20040365); J Cell Biol. 2008 Aug 25;182(4):685-701. (PMID: 18725538); Mol Cell Biol. 2010 Dec;30(24):5672-85. (PMID: 20937771); J Biol Chem. 2010 Feb 19;285(8):5941-53. (PMID: 20018885); J Biol Chem. 2003 Sep 5;278(36):34568-81. (PMID: 12813044); Plant Physiol. 2008 Sep;148(1):142-55. (PMID: 18614709); Nucleic Acids Res. 2002 Jan 1;30(1):235-8. (PMID: 11752303); J Biol Chem. 2008 Mar 14;283(11):6783-9. (PMID: 18174161); Nature. 2010 Jul 1;466(7302):68-76. (PMID: 20562859); Nat Cell Biol. 2010 Aug;12(8):747-57. (PMID: 20639872); J Cell Sci. 2008 Aug 15;121(Pt 16):2685-95. (PMID: 18653543); Autophagy. 2010 May;6(4):438-48. (PMID: 20484971); FEBS Lett. 2010 Apr 2;584(7):1374-8. (PMID: 20153326); Trends Biochem Sci. 2000 Mar;25(3):147-50. (PMID: 10694887); Plant J. 2010 May;62(3):483-93. (PMID: 20136727); EMBO J. 2000 Apr 3;19(7):1576-86. (PMID: 10747026); J Exp Bot. 2005 Jun;56(416):1575-90. (PMID: 15837708); Biochim Biophys Acta. 2009 Sep;1793(9):1397-403. (PMID: 19272302); Biochem Biophys Res Commun. 2008 Sep 12;374(1):33-7. (PMID: 18598672); Genetics. 1996 Dec;144(4):1425-36. (PMID: 8978031); Int J Plant Genomics. 2009;2009:451357. (PMID: 19730746); Genes Cells. 2008 Dec;13(12):1211-8. (PMID: 19021777); J Biol Chem. 2007 Aug 17;282(33):24131-45. (PMID: 17580304); Proc Int Conf Intell Syst Mol Biol. 1997;5:147-52. (PMID: 9322029); Development. 2008 Aug;135(14):2347-60. (PMID: 18567846); Curr Opin Plant Biol. 2005 Apr;8(2):165-73. (PMID: 15752997); Neurobiol Dis. 2009 Aug;35(2):302-10. (PMID: 19481605); Cell Microbiol. 2010 Aug;12(8):1026-35. (PMID: 20557314); Autophagy. 2009 Jul;5(5):732-3. (PMID: 19398892); Plant Physiol. 2009 Feb;149(2):885-93. (PMID: 19074627); Curr Opin Cell Biol. 2010 Apr;22(2):206-11. (PMID: 20045304); Plant Cell. 2009 Sep;21(9):2914-27. (PMID: 19773385); Cell. 2009 Jun 12;137(6):1062-75. (PMID: 19524509); Trends Plant Sci. 2002 May;7(5):193-5. (PMID: 11992820); Nucleic Acids Res. 2004 Jan 1;32(Database issue):D142-4. (PMID: 14681379); Plant Cell Physiol. 2003 Aug;44(8):795-802. (PMID: 12941871); Autophagy. 2010 Apr;6(3):330-44. (PMID: 20168092); Mol Cell. 2009 May 15;34(3):259-69. (PMID: 19450525); Plant Cell. 2004 Nov;16(11):2967-83. (PMID: 15494556); Plant Cell. 2003 Nov;15(11):2497-502. (PMID: 14600211); Mol Plant. 2010 Mar;3(2):347-60. (PMID: 20147370); Plant Physiol. 2007 Jan;143(1):291-9. (PMID: 17098847); FEBS Lett. 2010 Apr 2;584(7):1379-85. (PMID: 20083108); Autophagy. 2008 Oct;4(7):851-65. (PMID: 18670193); FEBS Lett. 2009 Jun 18;583(12):1846-52. (PMID: 19427866); Plant Physiol. 2005 Aug;138(4):2097-110. (PMID: 16040659); Nucleic Acids Res. 2005 Jan 20;33(2):511-8. (PMID: 15661851); J Exp Bot. 2005 Nov;56(421):2839-49. (PMID: 16157655); Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7. (PMID: 17712358) |
| Substance Nomenclature: | 0 (Adaptor Proteins, Signal Transducing); 0 (Arabidopsis Proteins); 0 (Autophagy-Related Protein 8 Family); 0 (Carrier Proteins); 0 (GABARAPL2 protein, human); 0 (Microfilament Proteins); 0 (NBR1 protein, Arabidopsis); 0 (Receptors, Cytoplasmic and Nuclear); 0 (SQSTM1 protein, human); 0 (Sequestosome-1 Protein); 70FD1KFU70 (Sulfur); N762921K75 (Nitrogen) |
| Entry Date(s): | Date Created: 20110615 Date Completed: 20120330 Latest Revision: 20231213 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3242614 |
| DOI: | 10.4161/auto.7.10.16617 |
| PMID: | 21670587 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't