Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays.
| Title: | Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays. |
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| Authors: | Kelling S; Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.; Huang J; Capener MJ; Elliott SR |
| Source: | Journal of breath research [J Breath Res] 2011 Sep; Vol. 5 (3), pp. 037106. Date of Electronic Publication: 2011 Jun 16. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: IOP Pub Country of Publication: England NLM ID: 101463871 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-7163 (Electronic) Linking ISSN: 17527155 NLM ISO Abbreviation: J Breath Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bristol, UK : IOP Pub. |
| MeSH Terms: | Air/*analysis ; Biosensing Techniques/*instrumentation ; Breath Tests/*instrumentation ; Microscopy, Interference/*instrumentation; Equipment Design ; Exhalation ; Humans ; Reproducibility of Results |
| Abstract: | Microcantilever (MC) sensors can provide ultrasensitive bio-chemical detection. Monitoring the bending response of large arrays of MC sensors coated with a library of receptors will produce a characteristic 'breath-print' corresponding to the breath composition; this promises to be suitable for non-invasive medical diagnostics. While MC arrays with hundreds of individual sensors can be produced readily, conventional MC readout methods are not suitable for the parallel readout of tens or hundreds of individual sensors. We have developed a MC sensor-array readout method based on phase-shifting interferometric microscopy (PSIM) which allows for the simultaneous monitoring of the response of all MCs within the field of view of the readout microscope optics. Based on this sensor technology, we have built an exhaled breath-analysis research instrument for the Point of Care Diagnostics Development Unit at the University of Leicester, UK. In this paper, we describe the PSIM readout system and the breath-analysis instrument that will be used to test sensor surface coatings and develop sensor sets with response patterns suitable for clear correlation to patients' health condition. |
| Entry Date(s): | Date Created: 20110617 Date Completed: 20120126 Latest Revision: 20110908 |
| Update Code: | 20260130 |
| DOI: | 10.1088/1752-7155/5/3/037106 |
| PMID: | 21677374 |
| Database: | MEDLINE |
Comparative Study; Journal Article