Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc.
| Title: | Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc. |
|---|---|
| Authors: | Khan I; Department of Pharmacy, University of Peshawar, 25120, Pakistan. inam_marwat333@yahoo.com; Nisar M; Shah MR; Shah H; Gilani SN; Gul F; Abdullah SM; Ismail M; Khan N; Kaleem WA; Qayum M; Khan H; Obaidullah; Samiullah; Ullah M |
| Source: | Fitoterapia [Fitoterapia] 2011 Oct; Vol. 82 (7), pp. 1003-7. Date of Electronic Publication: 2011 Jun 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : [Amsterdam] : Elsevier; Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| MeSH Terms: | Phytotherapy*; Anti-Inflammatory Agents/*therapeutic use ; Edema/*drug therapy ; Lipoxygenase Inhibitors/*therapeutic use ; Phenanthrenes/*therapeutic use ; Plant Extracts/*therapeutic use ; Taxus/*chemistry; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Edema/chemically induced ; Flavanones/pharmacology ; Lipoxygenase Inhibitors/isolation & purification ; Lipoxygenase Inhibitors/pharmacology ; Phenanthrenes/isolation & purification ; Phenanthrenes/pharmacology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Animals ; Carrageenan ; Disease Models, Animal ; Female ; Male ; Plant Bark ; Rats ; Rats, Wistar |
| Abstract: | Current study was conducted to identify constituents of Taxus wallichiana Zucc. that might be responsible for its folk use in anti-inflammatory conditions. Taxusabietane A was isolated from the bark extract of Taxus wallichiana Zucc. Taxusabietane A was analyzed for in-vitro and in-vivo anti-inflammatory activities using Lipoxygenase (LOX) inhibition assay and carrageenan-induced paw edema model. Taxusabietane A revealed considerable LOX inhibitory activity with the IC(50) value being 57 ± 0.31. Standard compound Baicalein showed the IC(50) value being 22.1 ± 0.03 μM. Taxusabietane A also showed significant (5 and 10 mg/kg) anti-inflammatory activity induced by carrageenan. However, this study highlighted the potential of Taxusabietane A to be further explored as a new lead compound for management of conditions associated with inflammation.; (Copyright © 2011 Elsevier B.V. All rights reserved.) |
| Substance Nomenclature: | 0 (Anti-Inflammatory Agents); 0 (Flavanones); 0 (Lipoxygenase Inhibitors); 0 (Phenanthrenes); 0 (Plant Extracts); 0 (taxusabietane A); 49QAH60606 (baicalein); 9000-07-1 (Carrageenan) |
| Entry Date(s): | Date Created: 20110625 Date Completed: 20120315 Latest Revision: 20121115 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.fitote.2011.06.003 |
| PMID: | 21699963 |
| Database: | MEDLINE |
Journal Article