Should we treat mild subclinical/mild hyperthyroidism? No.
| Title: | Should we treat mild subclinical/mild hyperthyroidism? No. |
|---|---|
| Authors: | Vanderpump MP; Department of Endocrinology, Royal Free Hampstead NHS Trust, Pond Street, London, NW3 2QG, United Kingdom. mark.vanderpump@nhs.net |
| Source: | European journal of internal medicine [Eur J Intern Med] 2011 Aug; Vol. 22 (4), pp. 330-3. Date of Electronic Publication: 2011 Apr 12. |
| Publication Type: | Journal Article; Comment |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : Amsterdam, The Netherlands : Elsevier Science; Original Publication: Basingstoke, Hampshire, UK : Published by the Macmillan Press on behalf of the European Association of Internal Medicine, c1989- |
| MeSH Terms: | Hyperthyroidism/*diagnosis ; Hyperthyroidism/*drug therapy ; Thyrotropin/*therapeutic use ; Thyroxine/*therapeutic use; Humans |
| Abstract: | The management of a patient with subclinical hyperthyroidism or mild thyroid over-activity is controversial. Subclinical hyperthyroidism is defined as a serum thyrotrophin (TSH) below the reference range but a normal thyroxine (T4) and triiodothyronine (T3) level in a patient who is either asymptomatic or has only non-specific symptoms. Epidemiological studies report an overall prevalence of approximately 3%, with men and women over 65 years and those in iodine deficient regions having the highest prevalence. Approximately 50% of subjects are taking levothyroxine. The aetiology for those with endogenous subclinical hyperthyroidism is Graves' disease, toxic nodular goitre or rarely a solitary toxic adenoma or thyroiditis. Non-thyroidal illness is an important cause of false positive low serum TSH test results. Subjects with low but detectable serum TSH values (0.1-0.4 mU/L) usually recover spontaneously when re-tested. It has been estimated that in those with an undetectable serum TSH ( |
| Comments: | Comment on: Eur J Intern Med. 2011 Aug;22(4):324-9. doi: 10.1016/j.ejim.2011.03.008.. (PMID: 21767746) |
| Substance Nomenclature: | 9002-71-5 (Thyrotropin); Q51BO43MG4 (Thyroxine) |
| Entry Date(s): | Date Created: 20110720 Date Completed: 20120103 Latest Revision: 20181201 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ejim.2011.03.009 |
| PMID: | 21767747 |
| Database: | MEDLINE |
Journal Article; Comment