Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice.
| Title: | Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice. |
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| Authors: | Brzóska K; Centre for Radiobiology and Biological Dosimetry, Warsaw, Poland.; Stępkowski TM; Kruszewski M |
| Source: | Redox report : communications in free radical research [Redox Rep] 2011; Vol. 16 (3), pp. 129-33. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2016- : Abingdon : Taylor & Francis; Original Publication: Edinburgh ; New York : Churchill Livingstone, c1994- |
| MeSH Terms: | Carrier Proteins/*metabolism ; Kidney/*metabolism ; Nuclear Proteins/*metabolism ; Spleen/*metabolism ; Superoxide Dismutase/*deficiency; Liver/metabolism ; NF-kappa B p50 Subunit/genetics ; NF-kappa B p50 Subunit/metabolism ; NFI Transcription Factors/genetics ; NFI Transcription Factors/metabolism ; RNA, Messenger/metabolism ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism ; Animals ; Dioxygenases ; Female ; Gene Expression Regulation ; Genotype ; Male ; Mice ; Mice, 129 Strain ; Mice, Knockout ; Models, Animal ; Oxidative Stress ; Promoter Regions, Genetic ; Proto-Oncogene Mas ; Transcription, Genetic ; Up-Regulation |
| Abstract: | Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-κB1(p50). Alterations of pirin expression were observed in various tumors and after exposure to pro-carcinogenic oxidative stressors. The aim of the present work was to study the level of pirin transcription in an in vivo model of oxidative stress, namely, in Sod1-deficient mice. We have found that Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain. We have also shown that similarly to its human ortholog, the mouse Pir gene transcription level varies significantly between organs. The highest expression was found in the liver and the lowest in the spleen and kidney. Based on literature data, we propose the involvement of Nrf2, AP-1, and NF-κB transcription factors in Pir up-regulation in Sod1(-/-) mice. |
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| Substance Nomenclature: | 0 (Carrier Proteins); 0 (MAS1 protein, human); 0 (NF-kappa B p50 Subunit); 0 (NFI Transcription Factors); 0 (Nfix protein, mouse); 0 (Nuclear Proteins); 0 (Proto-Oncogene Mas); 0 (RNA, Messenger); 0 (Transcription Factor AP-1); EC 1.13.11.- (Dioxygenases); EC 1.13.11.- (Pir protein, mouse); EC 1.15.1.1 (Superoxide Dismutase) |
| Entry Date(s): | Date Created: 20110802 Date Completed: 20111128 Latest Revision: 20211203 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC6837407 |
| DOI: | 10.1179/1351000211Y.0000000002 |
| PMID: | 21801495 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't