Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.
| Title: | Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo. |
|---|---|
| Authors: | Simrick S; Department of Craniofacial Development, King's College London, Floor 27, Guy's Tower, London, SE1 9RT, UK.; Lickert H; Basson MA |
| Source: | Developmental biology [Dev Biol] 2011 Oct 01; Vol. 358 (1), pp. 147-55. Date of Electronic Publication: 2011 Jul 23. |
| Publication Type: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: San Diego, CA : Elsevier; Original Publication: New York. |
| MeSH Terms: | Branchial Region/*innervation ; Fibroblast Growth Factor 8/*metabolism ; Ganglia, Sensory/*embryology ; Gene Expression Regulation, Developmental/*genetics ; Membrane Proteins/*physiology ; Phosphoproteins/*physiology ; Signal Transduction/*genetics; Branchial Region/embryology ; Facial Nerve/abnormalities ; Fibroblast Growth Factor 8/genetics ; Glossopharyngeal Nerve/abnormalities ; Membrane Proteins/genetics ; Neural Crest/embryology ; Phosphoproteins/genetics ; Vagus Nerve/abnormalities ; Adaptor Proteins, Signal Transducing ; Animals ; Genotype ; Haploinsufficiency ; Immunohistochemistry ; In Situ Hybridization ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Knockout ; Protein Serine-Threonine Kinases |
| Abstract: | Fibroblast growth factor (FGF) signalling has important roles in the development of the embryonic pharyngeal (branchial) arches, but its effects on innervation of the arches and associated structures have not been studied extensively. We investigated the consequences of deleting two receptor tyrosine kinase (RTK) antagonists of the Sprouty (Spry) gene family on the early development of the branchial nerves. The morphology of the facial, glossopharyngeal and vagus nerves are abnormal in Spry1-/-;Spry2-/- embryos. We identify specific defects in the epibranchial placodes and neural crest, which contribute sensory neurons and glia to these nerves. A dissection of the tissue-specific roles of these genes in branchial nerve development shows that Sprouty gene deletion in the pharyngeal epithelia can affect both placode formation and neural crest fate. However, epithelial-specific gene deletion only results in defects in the facial nerve and not the glossopharyngeal and vagus nerves, suggesting that the facial nerve is most sensitive to perturbations in RTK signalling. Reducing the Fgf8 gene dosage only partially rescued defects in the glossopharyngeal nerve and was not sufficient to rescue facial nerve defects, suggesting that FGF8 is functionally redundant with other RTK ligands during facial nerve development.; (Copyright © 2011 Elsevier Inc. All rights reserved.) |
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| Grant Information: | 091475 United Kingdom Wellcome Trust; G0601104 United Kingdom Medical Research Council |
| Substance Nomenclature: | 0 (Adaptor Proteins, Signal Transducing); 0 (Fgf8 protein, mouse); 0 (Intracellular Signaling Peptides and Proteins); 0 (Membrane Proteins); 0 (Phosphoproteins); 0 (Spry1 protein, mouse); 148997-75-5 (Fibroblast Growth Factor 8); EC 2.7.11.1 (Protein Serine-Threonine Kinases); EC 2.7.11.1 (Spry2 protein, mouse) |
| Entry Date(s): | Date Created: 20110803 Date Completed: 20111122 Latest Revision: 20211203 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3368431 |
| DOI: | 10.1016/j.ydbio.2011.07.024 |
| PMID: | 21806979 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't