| Title: |
Tissue-specific Ctr1 Gene Expression and in silico Analysis of Its Putative Protein Product. |
| Authors: |
Samsonov, Sergey A.; Nordlund, Eija; Platonova, Natalia A.; Skvortsov, Alexey N.; Tsymbalenko, Nadezhda V.; Puchkova, Ludmila V. |
| Source: |
AIP Conference Proceedings; 2006, Vol. 851 Issue 1, p185-191, 7p |
| Subject Terms: |
COPPER metabolism genetics; COPPER in the body; LABORATORY rats; GENE expression; COPPER toxicity testing; PHYSIOLOGY |
| Abstract: |
Investigations of the links between Ctr1 gene activity and copper status in rat organs (liver, cerebellum, choroid plexus and mammary gland) with distinct types of copper metabolism as well as theoretical analysis of CTR1 domains structure were carried out in the research. The results suggest that (i) activity of mammalian Ctr1 gene is tissue-specific regulated at least by two different mechanisms: the gene activity is repressed by high intracellular Cu content and is activated/inactivated dependently on the cuproenzymes synthesis level required by physiological conditions. (ii) Multimerized conservative transmembrane domains 2 and 3 form the channel with copper binding amino acid side chains groups oriented inside this channel. These groups can transfer copper to the cytosolic domain, where Cu binds to CTR1 cytosolic HCH-motifs and can be further transferred to CXXC-motif of any known Cu(I)-chaperon. © 2006 American Institute of Physics [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |