Matrix metalloproteinases and their role in oncogenesis: a review.
| Title: | Matrix metalloproteinases and their role in oncogenesis: a review. |
|---|---|
| Authors: | Pytliak M; Department of Nursing, Medical Faculty, University of P.J. Safarik and University Hospital of L. Pasteur, Košice, Slovakia. m_pytliak@hotmail.com; Vargová V; Mechírová V |
| Source: | Onkologie [Onkologie] 2012; Vol. 35 (1-2), pp. 49-53. Date of Electronic Publication: 2012 Jan 23. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Karger Country of Publication: Switzerland NLM ID: 7808556 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0240 (Electronic) Linking ISSN: 0378584X NLM ISO Abbreviation: Onkologie Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, New York, Karger. |
| MeSH Terms: | Cell Transformation, Neoplastic*; Extracellular Matrix/*metabolism ; Neoplasms/*metabolism ; Neoplasms/*pathology; Animals ; Humans |
| Abstract: | The extracellular matrix (ECM) provides a physical framework for the cells and functions as a gel medium. Remodeling of the ECM is crucial during physiological cell migration, proliferation, growth, and development. Thus, the interaction between cells and the ECM plays a key role in normal development and differentiation of organisms. However, remodeling of the ECM also occurs in many pathological states. Changes in the ECM are regulated by a system of proteolytic enzymes that are responsible for the proteolysis of a huge quantity of ECM components. Matrix metalloproteinases (MMPs) represent the main group of regulating proteases in the ECM. By regulating the composition and integrity of the ECM, this group of enzymes is essential for cell proliferation, differentiation, and processes of apoptosis. However, deregulation or activation of MMP expression is a feature of numerous pathologic conditions including tumorigenesis and metastasis. The aim of this article is to provide a brief overview of MMPs, their nomenclature and structure, and their role in the development of tumors and metastases.; (Copyright © 2012 S. Karger AG, Basel.) |
| Entry Date(s): | Date Created: 20120208 Date Completed: 20120612 Latest Revision: 20120207 |
| Update Code: | 20260130 |
| DOI: | 10.1159/000336304 |
| PMID: | 22310347 |
| Database: | MEDLINE |
Journal Article