Matrix metalloproteinases.
| Title: | Matrix metalloproteinases. |
|---|---|
| Authors: | Vargová V; 3rd Internal Clinic, Faculty of Medicine, UPJS, Kosice, Slovakia. viola.vargova@upjs.sk; Pytliak M; Mechírová V |
| Source: | Experientia supplementum (2012) [Exp Suppl] 2012; Vol. 103, pp. 1-33. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Springer Basel AG Country of Publication: Switzerland NLM ID: 101738007 Publication Model: Print Cited Medium: Print ISSN: 1664-431X (Print) Linking ISSN: 1664431X NLM ISO Abbreviation: Exp Suppl Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel : Springer Basel AG |
| MeSH Terms: | Matrix Metalloproteinases/*metabolism; Matrix Metalloproteinases/chemistry ; Catalytic Domain ; Humans ; Proteolysis ; Structure-Activity Relationship |
| Abstract: | Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many pathological states as well. Changes in extracellular matrix are regulated by a system of proteolytic enzymes that are responsible for proteolysis of huge quantity of extracellular matrix components. Matrix metalloproteinases (MMPs) represent the main group of regulating proteases in ECM. Ability of matrix metalloproteinases to modify the structural integrity of tissues is essential for certain aspects of normal physiology and pathology. The ability to process molecules such as growth factors, receptors, adhesion molecules, other proteinases, and proteinase inhibitors makes MMPs potent controllers of physiological and pathological events in the cell microenvironment. Overactivation of MMPs has been implicated in numerous disease states. |
| Substance Nomenclature: | EC 3.4.24.- (Matrix Metalloproteinases) |
| Entry Date(s): | Date Created: 20120531 Date Completed: 20120606 Latest Revision: 20181206 |
| Update Code: | 20260130 |
| DOI: | 10.1007/978-3-0348-0364-9_1 |
| PMID: | 22642188 |
| Database: | MEDLINE |
Journal Article; Review