The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre.
| Title: | The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre. |
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| Authors: | Bellamy CO; Division of Pathology, University of Edinburgh, Queen's Medical Research Institute, University of Edinburgh, UK. c.bellamy@ed.ac.uk; Maxwell RS; Prost S; Azodo IA; Powell JJ; Manning JR |
| Source: | Histopathology [Histopathology] 2013 Feb; Vol. 62 (3), pp. 431-45. Date of Electronic Publication: 2012 Sep 28. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, Blackwell Scientific Publications. |
| MeSH Terms: | Immunophenotyping*; Adenoma, Liver Cell/*classification ; Adenoma, Liver Cell/*pathology ; Liver Neoplasms/*classification ; Liver Neoplasms/*pathology; Adenoma, Liver Cell/immunology ; Liver Neoplasms/immunology ; Adult ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; United Kingdom |
| Abstract: | Aims: To determine the utility of immunophenotyping for classification of hepatocellular adenomas resected at one Scottish centre.; Methods and Results: This study comprised a retrospective review and immunophenotyping of consecutive resected benign hepatocellular tumours. Fifty-five patients (seven men) had 64 adenomas and 26 focal nodular hyperplasias (FNHs) resected. Map-like glutamine synthetase (GS) staining was specific for FNH. Immunophenotyping changed the morphological typing for three adenomas and resolved 16 of 18 unclassified or equivocal cases, revealing GS positivity in these (seven) and four others. Steatotic/liver fatty acid binding protein-deficient adenomas were the commonest type in women (12/29 women, 41%) but were absent from men. Where one of multiple adenomas was morphologically unclassified, there was still a shared immunophenotype. Diffuse CD34 positivity correlated with GS positivity or unclassified status (P |
| Grant Information: | G0901697 United Kingdom MRC_ Medical Research Council |
| Entry Date(s): | Date Created: 20121002 Date Completed: 20130724 Latest Revision: 20260128 |
| Update Code: | 20260130 |
| DOI: | 10.1111/his.12011 |
| PMID: | 23020256 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't