Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging.
| Title: | Polymeric nanoparticles with sequential and multiple FRET cascade mechanisms for multicolor and multiplexed imaging. |
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| Authors: | Wagh A; Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Department 2665, PO Box 6050, Fargo, ND 58108-6050, USA.; Jyoti F; Mallik S; Qian S; Leclerc E; Law B |
| Source: | Small (Weinheim an der Bergstrasse, Germany) [Small] 2013 Jun 24; Vol. 9 (12), pp. 2129-39. Date of Electronic Publication: 2013 Jan 29. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Weinheim, Germany : Wiley-VCH, c2005- |
| MeSH Terms: | Diagnostic Imaging/*methods ; Fluorescence Resonance Energy Transfer/*methods ; Nanoparticles/*chemistry ; Polymers/*chemistry; Lactic Acid/chemistry ; Polyethylene Glycols/chemistry ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer |
| Abstract: | The ability to map multiple biomarkers at the same time has far-reaching biomedical and diagnostic applications. Here, a series of biocompatible poly(D,L-lactic-co-glycolic acid) and polyethylene glycol particles for multicolor and multiplexed imaging are reported. More than 30 particle formulations that exhibit distinct emission signatures (ranging from the visible to NIR wavelength region) are designed and synthesized. These particles are encapsulated with combinations of carbocyanine-based fluorophores DiO, Dil, DiD, and DiR, and are characterized as |
| Substance Nomenclature: | 0 (Polymers); 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 3WJQ0SDW1A (Polyethylene Glycols) |
| Entry Date(s): | Date Created: 20130130 Date Completed: 20140113 Latest Revision: 20181203 |
| Update Code: | 20260130 |
| DOI: | 10.1002/smll.201202655 |
| PMID: | 23359548 |
| Database: | MEDLINE |
Journal Article