Comparison of the sentinel node procedure between patients with multifocal and unifocal breast cancer in the EORTC 10981-22023 AMAROS Trial: identification rate and nodal outcome.
| Title: | Comparison of the sentinel node procedure between patients with multifocal and unifocal breast cancer in the EORTC 10981-22023 AMAROS Trial: identification rate and nodal outcome. |
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| Authors: | Donker M; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Straver ME; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; van Tienhoven G; Department of Radiation Oncology, Academic Medical Centre, Amsterdam, The Netherlands.; van de Velde CJ; Department of Surgery, University Medical Centre, Leiden, The Netherlands.; Mansel RE; Department of Surgery, Cardiff University, Cardiff, Wales, United Kingdom.; Litière S; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.; Werutsky G; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.; Duez NJ; European Organisation for Research and Treatment of Cancer, Brussels, Belgium.; Orzalesi L; Breast Unit, Careggi University Hospital, Florence, Italy.; Bouma WH; Department of Surgery, Gelre Hospital, Apeldoorn, The Netherlands.; van der Mijle H; Department of Surgery, Nij Smellinghe Hospital, Drachten, The Netherlands.; Nieuwenhuijzen GA; Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands.; Veltkamp SC; Department of Surgery, Amstelland Hospital, Amstelveen, The Netherlands.; Helen Westenberg A; Institute for Radiation Oncology Arnhem, Arnhem, The Netherlands.; Rutgers EJ; Department of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: e.rutgers@nki.nl. |
| Source: | European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2013 Jun; Vol. 49 (9), pp. 2093-100. Date of Electronic Publication: 2013 Mar 19. |
| Publication Type: | Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Ltd; Original Publication: Oxford ; New York : Pergamon Press, c1990- |
| MeSH Terms: | Breast Neoplasms/*pathology ; Lymph Nodes/*pathology; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Lymph Node Excision/methods ; Sentinel Lymph Node Biopsy/methods ; Adult ; Aged ; Axilla ; Female ; Humans ; Lymphatic Metastasis ; Middle Aged ; Prospective Studies ; Treatment Outcome |
| Abstract: | Introduction: Multifocal breast cancer is associated with a higher risk of nodal involvement compared to unifocal breast cancer and the drainage pattern from multifocal localisations may be different. For this reason, the value of the sentinel node biopsy (SNB) procedure for this indication is debated. The aim of the current analysis was to evaluate the sentinel node identification rate and nodal involvement in patients with a multifocal tumour in the EORTC 10981-22023 AMAROS trial.; Patients and Methods: From the first 4000 registered patients, 342 were identified with a multifocal tumour on histological examination and compared to a randomly selected control group of 684 patients with a unifocal tumour. The outcome of the SNB was assessed.; Results: The sentinel node was identified in 96% of the patients with a multifocal tumour and in 98% of those with unifocal disease. In the multifocal group, 51% had a metastasis in the sentinel node compared to 28% in the unifocal group; and further nodal involvement after a positive sentinel node was found in 40% (38/95) and 39% (39/101) respectively.; Conclusion: In this prospective international multicentre study, the 96% detection rate indicates that the SNB procedure can be highly effective in patients with a multifocal tumour. Though the tumour-positive rate of the sentinel node was twice as high in the multifocal group compared to the unifocal group, further nodal involvement after a positive sentinel node was similar in both groups. This suggests that the SNB procedure is safe in patients with multifocal breast cancer.; (Copyright © 2013 Elsevier Ltd. All rights reserved.) |
| Grant Information: | 2U10 CA11488-28 United States CA NCI NIH HHS; 5U10 CA011488-38 United States CA NCI NIH HHS |
| Molecular Sequence: | ClinicalTrials.gov NCT00014612 |
| Entry Date(s): | Date Created: 20130326 Date Completed: 20140409 Latest Revision: 20220318 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.ejca.2013.02.017 |
| PMID: | 23522754 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't