Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking.
| Title: | Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking. |
|---|---|
| Authors: | Simrick S; Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield UB9 6JH, United Kingdom.; Schindler RF; Poon KL; Brand T |
| Source: | Trends in cardiovascular medicine [Trends Cardiovasc Med] 2013 Oct; Vol. 23 (7), pp. 257-63. Date of Electronic Publication: 2013 Apr 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Publishing Country of Publication: United States NLM ID: 9108337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2615 (Electronic) Linking ISSN: 10501738 NLM ISO Abbreviation: Trends Cardiovasc Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York Ny : Elsevier Science Publishing; Original Publication: New York : Elsevier Science Pub. Co. |
| MeSH Terms: | Cell Adhesion Molecules*/genetics ; Cell Adhesion Molecules*/metabolism ; Muscle Proteins*/genetics ; Muscle Proteins*/metabolism; Heart Conduction System/*metabolism ; Myocardium/*metabolism; Ion Channels/metabolism ; Stress, Physiological/physiology ; Adaptation, Physiological ; Animals ; Humans ; Mice ; Models, Biological ; Mutation |
| Abstract: | An intricate network of ion channels and pumps are involved in generating a diastolic pacemaker potential, which is transmitted to the working myocardium with the help of the cardiac conduction system. The principles of cardiac pacemaking are reasonably well understood, however, the mechanism by which the heart increases its beating frequency in response to adrenergic stimulation has not been fully worked out. The Popeye domain-containing (Popdc) genes encode plasma membrane-localized proteins that are able to bind cAMP with high affinity; mice with null mutations in Popdc1 or 2 have a stress-induced pacemaker dysfunction. The phenotype in both mutants develops in an age-dependent manner and thus may model pacemaker dysfunction in man, as well as provide novel mechanistic insights into the process of pacemaker adaptation to stress.; (Copyright © 2013 Elsevier Inc. All rights reserved.) |
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| Grant Information: | MR/J010383/1 United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Indexing Agency: NLM Local ID #: EMS53066. |
| Substance Nomenclature: | 0 (Cell Adhesion Molecules); 0 (Ion Channels); 0 (Muscle Proteins); 0 (Popdc2 protein, mouse) |
| Entry Date(s): | Date Created: 20130409 Date Completed: 20140506 Latest Revision: 20250529 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4916994 |
| DOI: | 10.1016/j.tcm.2013.02.002 |
| PMID: | 23562093 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Review