Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice.
| Title: | Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice. |
|---|---|
| Authors: | Halcomb ME; Department of Psychology, Indiana University Purdue University, Indianapolis, IN, USA.; Gould TD; Grahame NJ |
| Source: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2013 Sep; Vol. 38 (10), pp. 1937-44. Date of Electronic Publication: 2013 Apr 12. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Nature Publishing Group; Original Publication: [New York, NY] : Elsevier, [c1987- |
| MeSH Terms: | Choice Behavior/*drug effects ; Impulsive Behavior/*drug therapy ; Lithium Chloride/*pharmacology ; Lithium Chloride/*therapeutic use ; Valproic Acid/*pharmacology ; Valproic Acid/*therapeutic use; Antimanic Agents/pharmacology ; Antimanic Agents/therapeutic use ; Conditioning, Operant/drug effects ; Animals ; Female ; Male ; Mice ; Mice, Inbred Strains |
| Abstract: | Both lithium and valproate are well-established treatments for bipolar disorder. Studies have also found that lithium is effective at reducing suicidal behaviors in patients with mood disorders. Impulsivity is a validated endophenotype of both bipolar disorder and suicidal behavior. We assessed effects of treatment with lithium or valproate on cognitive impulsivity in selectively bred mice previously shown to manifest relatively high levels of cognitive impulsivity. Mice were trained in the delay-discounting paradigm, a measure of cognitive impulsivity reflecting a behavioral bias towards immediacy, and then treated with lithium, valproate, or control chow. After 3 weeks of drug treatment, mice were tested at various delays to a large, delayed reward. Drug treatment continued during this time. Lithium reduced impulsivity, whereas valproate had no effect on choice behavior. Both drugs increased the number of choice trials and reinforcer intake, but effects on choice behavior did not depend on these motivational changes. To our knowledge, this is the first study demonstrating lithium's effects to reduce cognitive impulsivity. Future studies may focus on the ability of putative pharmacotherapies for patients at risk for bipolar disorder or suicide to modify the impulsive choice dimension of this diseases. |
| References: | Am J Psychiatry. 2008 Oct;165(10):1356-7; author reply 1357. (PMID: 18829890); Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8455-9. (PMID: 8710892); JAMA. 2003 Sep 17;290(11):1467-73. (PMID: 13129986); Psychopharmacology (Berl). 2012 Jan;219(2):421-32. (PMID: 21947315); Alcohol Clin Exp Res. 2010 Aug;34(8):1363-75. (PMID: 20491739); Am J Psychiatry. 2004 Aug;161(8):1433-41. (PMID: 15285970); J Exp Anal Behav. 1980 Sep;34(2):135-47. (PMID: 16812184); Genes Brain Behav. 2011 Jun;10(4):434-43. (PMID: 21306560); Expert Opin Ther Targets. 2006 Jun;10(3):377-92. (PMID: 16706678); Trends Pharmacol Sci. 2003 Sep;24(9):441-3. (PMID: 12967765); J Clin Psychiatry. 2007 Mar;68(3):380-3. (PMID: 17388706); Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1333-8. (PMID: 18212115); J Neurosci. 2004 Jul 28;24(30):6791-8. (PMID: 15282284); Arch Int Pharmacodyn Ther. 1976 Jul;222(1):116-24. (PMID: 136232); J Neurosci. 2004 Jul 21;24(29):6590-9. (PMID: 15269271); Am J Psychiatry. 2005 Jan;162(1):137-45. (PMID: 15625212); J Exp Anal Behav. 1997 May;67(3):353-66. (PMID: 9163939); Indian J Exp Biol. 1989 Nov;27(11):950-4. (PMID: 2559891); Am J Psychiatry. 2011 Oct;168(10):1050-6. (PMID: 21768611); J Clin Psychiatry. 2011 Nov;72(11):1452-64. (PMID: 22054050); J Exp Anal Behav. 1972 Jan;17(1):15-22. (PMID: 16811561); Am J Psychiatry. 2007 Sep;164(9):1364-70. (PMID: 17728421); Psychopharmacology (Berl). 2000 Nov;152(4):390-7. (PMID: 11140331); Alcohol Clin Exp Res. 2009 Jul;33(7):1294-303. (PMID: 19389183); Neuropharmacology. 2008 Mar;54(3):577-87. (PMID: 18096191); Bipolar Disord. 2012 Aug;14(5):565-70. (PMID: 22805501); Behav Genet. 2012 Mar;42(2):313-22. (PMID: 21989731); Biol Psychiatry. 2009 Apr 1;65(7):556-63. (PMID: 19201395); Ann N Y Acad Sci. 1997 Dec 29;836:339-51. (PMID: 9616808); Addict Biol. 2013 Nov;18(6):921-9. (PMID: 22126215); J Affect Disord. 2003 Jan;73(1-2):105-11. (PMID: 12507743); Pharmacol Biochem Behav. 2010 Jan;94(3):380-6. (PMID: 19800363); Neuropsychopharmacology. 2004 Jan;29(1):32-8. (PMID: 12942141); Bipolar Disord. 2006 Oct;8(5 Pt 2):625-39. (PMID: 17042835); Genes Brain Behav. 2006 Mar;5(2):113-9. (PMID: 16507002); J Neuropsychiatry Clin Neurosci. 2002 Summer;14(3):289-95. (PMID: 12154153); J Affect Disord. 2007 Jun;100(1-3):227-31. (PMID: 17097740); Bipolar Disord. 2006 Oct;8(5 Pt 2):551-7. (PMID: 17042828); J Affect Disord. 2008 Apr;107(1-3):23-8. (PMID: 17707087); J Psychopharmacol. 1999;13(2):180-92. (PMID: 10475725); Clin Neurosci Res. 2002 Dec;2(3-4):193-212. (PMID: 22707923); Neuropsychopharmacology. 2004 Jul;29(7):1331-43. (PMID: 15054475); Psychopharmacology (Berl). 1993;111(2):239-43. (PMID: 7870958); Science. 1981 Sep 25;213(4515):1529-31. (PMID: 6269180); Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104. (PMID: 15044694); Annu Rev Pharmacol Toxicol. 2009;49:175-98. (PMID: 18834309); Pharmacol Biochem Behav. 1986 Jan;24(1):9-13. (PMID: 3003763); Eur Neuropsychopharmacol. 2007 Apr;17(5):313-20. (PMID: 17140772); Neuropsychopharmacology. 2004 Aug;29(8):1426-31. (PMID: 15039769); Psychiatry Res. 2001 Mar 25;101(2):195-7. (PMID: 11286822); J Psychiatry Neurosci. 2005 Nov;30(6):398-408. (PMID: 16327873); Neuropsychopharmacology. 2002 Apr;26(4):530-6. (PMID: 11927177); Am J Psychiatry. 2001 Mar;158(3):420-6. (PMID: 11229983); Transl Psychiatry. 2011;1:. (PMID: 21761009); Clin Psychol Rev. 2006 Aug;26(4):379-95. (PMID: 16504359); J Affect Disord. 2013 Jan 25;144(3):240-7. (PMID: 22901401); Am J Psychiatry. 2004 Feb;161(2):217-22. (PMID: 14754766); Neuropsychopharmacology. 2007 Oct;32(10):2173-83. (PMID: 17299510); Int J Neuropsychopharmacol. 2004 Dec;7(4):387-90. (PMID: 15315719); Am J Psychiatry. 2005 Oct;162(10):1805-19. (PMID: 16199826) |
| Grant Information: | P60 AA007611 United States AA NIAAA NIH HHS; R01 MH091816 United States MH NIMH NIH HHS; MH091816 United States MH NIMH NIH HHS |
| Substance Nomenclature: | 0 (Antimanic Agents); 614OI1Z5WI (Valproic Acid); G4962QA067 (Lithium Chloride) |
| Entry Date(s): | Date Created: 20130416 Date Completed: 20140324 Latest Revision: 20211021 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3746699 |
| DOI: | 10.1038/npp.2013.89 |
| PMID: | 23584261 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural