Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis.
| Title: | Pre-operative hypoalbuminaemia predicts poor overall survival in rectal cancer: a retrospective cohort analysis. |
|---|---|
| Authors: | Chandrasinghe PC; Department of Surgery, North Colombo Teaching Hospital, Ragama, Sri Lanka.; Ediriweera DS; Department of Surgery, North Colombo Teaching Hospital, Ragama, Sri Lanka.; Kumarage SK; Department of Surgery, North Colombo Teaching Hospital, Ragama, Sri Lanka.; Deen KI; Department of Surgery, North Colombo Teaching Hospital, Ragama, Sri Lanka. |
| Source: | BMC clinical pathology [BMC Clin Pathol] 2013 Apr 16; Vol. 13, pp. 12. Date of Electronic Publication: 2013 Apr 16. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101088665 Publication Model: Electronic Cited Medium: Print ISSN: 1472-6890 (Print) Linking ISSN: 14726890 NLM ISO Abbreviation: BMC Clin Pathol Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001]-[2019] |
| Abstract: | Background: Serum albumin is a marker of nutrition and inflammation. It has recently emerged as a predictor of outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum albumin would predict survival after resection for rectal cancer.; Method: 226 Patients with rectal cancer of all stages undergoing resection with curative intent were studied. Kaplan-Meier curves analysed survival based on a pre-operative albumin level of 35 g/L. We sought for significant associations of survival with age, sex, stage, tumour site, use of neoadjuvant chemoradiation, microscopic positive resection margins, differentiation, angio, peri-neural, and lymphovascular invasion using individual variable analysis. Multifactorial analysis was performed using type III analysis with Weibull hazard model and Cox-proportional hazard model. Significance was assigned to a P value |
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| Entry Date(s): | Date Created: 20130418 Date Completed: 20130430 Latest Revision: 20211021 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3637439 |
| DOI: | 10.1186/1472-6890-13-12 |
| PMID: | 23590192 |
| Database: | MEDLINE |
Journal Article