Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome.
| Title: | Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome. |
|---|---|
| Authors: | Sagiv O; The Bruce Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Haifa, Israel.; Fishelson-Arev T; Buckman G; Mathalone N; Wolfson J; Segev E; Peled R; Lavi I; Geyer O |
| Source: | Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2014 Mar; Vol. 42 (2), pp. 132-8. Date of Electronic Publication: 2013 Jul 15. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia; Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000- |
| MeSH Terms: | Tomography, Optical Coherence*; Nerve Fibers/*pathology ; Optic Disk/*pathology ; Optic Nerve Diseases/*diagnosis ; Retinal Ganglion Cells/*pathology ; Sleep Apnea, Obstructive/*diagnosis; Body Mass Index ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Oxygen Consumption ; Polysomnography |
| Abstract: | Background: The study aims to investigate whether retinal nerve fibre layer (RNFL) abnormalities can be detected in patients with obstructive sleep apnoea/hypopnoea syndrome with normally appearing optic disc.; Design: This is an observational case-control study.; Participants: One hundred and eight consecutive patients with moderate or severe obstructive sleep apnoea/hypopnoea syndrome (OSAHS) as determined by overnight polysomnography and normal looking discs and 108 age-matched healthy controls were included in the study.; Methods: All patients underwent RNFL examinations by optical coherence tomography using fast retinal nerve fibre layer thickness scan.; Main Outcome Measures: The main outcome measure was RNFL thickness.; Results: Multivariate regression analysis results showed that the RNFL was thinner for a patient with OSAHS than that of a normal control in the average by 4.20 μm (P < 0.003), in the superior quadrant by 4.83 μm (P = 0.028) and in the inferior quadrant by 5.19 μm (P = 0.016). RNFL thickness did not correlate with the severity of the disease.; Conclusions: RNFL thinning was detected in normal-looking discs of patients with advanced OSAHS, but the extent of this thinning did not correlate with the severity of the disease. Longitudinal follow-up is needed to clarify whether RNFL thinning in OSAHS patients with normal clinically appearing optic nerves will eventually lead to glaucoma.; (© 2013 Royal Australian and New Zealand College of Ophthalmologists.) |
| Contributed Indexing: | Keywords: glaucoma; obstructive sleep apnoea/hypopnoea syndrome; optical coherence tomography; retinal nerve fibre layer |
| Molecular Sequence: | ClinicalTrials.gov NCT01188291 |
| Entry Date(s): | Date Created: 20130620 Date Completed: 20140811 Latest Revision: 20220321 |
| Update Code: | 20260130 |
| DOI: | 10.1111/ceo.12145 |
| PMID: | 23777553 |
| Database: | MEDLINE |
Journal Article; Observational Study