Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease.
| Title: | Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease. |
|---|---|
| Authors: | Grdanoska T; Institute of Microbiology and Parasitology.; Zafirovska P; Jaglikovski B; Pavlovska I; Zafirova B; Tosheska-Trajkovska K; Trajkovska-Dokic E; Petrovska M; Cekovska Z; Kondova-Topuzovska I; Georgievska-Ismail L; Panovski N |
| Source: | Materia socio-medica [Mater Sociomed] 2012; Vol. 24 (3), pp. 151-6. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Academy of Medical Sciences of Bosnia & Herzegovina Country of Publication: Bosnia and Herzegovina NLM ID: 101281595 Publication Model: Print Cited Medium: Print ISSN: 1512-7680 (Print) Linking ISSN: 15127680 NLM ISO Abbreviation: Mater Sociomed Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: Sarajevo, Bosnia and Herzegovina : Academy of Medical Sciences of Bosnia & Herzegovina; Original Publication: Sarajevo : Udruženje za socijalnu medicinu-javno zdravstvo BiH |
| Abstract: | Background: Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori.; Aim: To examine the association between serum markers of Chlamydia pneumoniae and Helicobacter pylori infection and markers of myocardial damage. in patients with acute coronary syndrome (ACS), with chronic coronary artery disease (CAD) and in-control group.; Material and Methods: Sera were taken from a total of 153 subjects. Subjects were divided in three groups: 64 patients with ACS; 53 patients with CAD and a group of 35 conditionally healthy individuals. Analysis of patients' sera for IgG antibodies to H. pylori and markers for myocardial damage was done on the Immulite system. The presence of specific IgG and IgA antibodies to C. pneumoniae was determined with MIF, Sero FIA (Savyon Diagnostics, Israel). Statistical analysis of data was done using the statistical program SPSS (Statistical Package for Social Sciences), version 13.; Results and Discussion: There was a high significant difference in troponin levels between the three groups of subjects (p=0.0000). Levels of creatine kinase isoenzyme (CK-MB) were highest in the ACS group (500.0 ng/mL). There was a statistically significant difference between CG subjects and ACS patients due to more frequent detection of antichlamydial IgA antibodies in patients with acute coronary syndrome. Positive serum immune response for Helicobacter pylori was 17 (53.1%) and 29 (80.6%), respectively.; Conclusion: Increased IgA antibody titers for C. Pneumoniae, increased CRP values as well as classic markers of myocardial damage are risk factors for coronary events. |
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| Contributed Indexing: | Keywords: Chlamydia pneumoniae and Helicobacter pylori.; chronic infections; markers of cardiac damage |
| Entry Date(s): | Date Created: 20130808 Date Completed: 20130807 Latest Revision: 20211021 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3732349 |
| DOI: | 10.5455/msm.2012.24.151-156 |
| PMID: | 23922522 |
| Database: | MEDLINE |
Journal Article