Clinical versus rapid molecular HIV diagnosis in hospitalized African infants: a randomized controlled trial simulating point-of-care infant testing.
| Title: | Clinical versus rapid molecular HIV diagnosis in hospitalized African infants: a randomized controlled trial simulating point-of-care infant testing. |
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| Authors: | McCollum ED; University of North Carolina Project, Lilongwe, Malawi; †Department of Pediatrics, Division of Pulmonology, Johns Hopkins School of Medicine, Baltimore, MD; ‡Department of Pediatrics, Baylor College of Medicine, Houston, TX; §Department of Pediatrics, Division of Infectious Diseases, University of Colorado, Aurora, CO; ‖Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi; and ¶Department of Medicine, Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC.; Preidis GA; Maliwichi M; Olson D; McCrary LM; Kazembe PN; Horst Cv; Hoffman I; Hosseinipour MC |
| Source: | Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2014 May 01; Vol. 66 (1), pp. e23-30. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999- |
| MeSH Terms: | Point-of-Care Systems*; Anti-Retroviral Agents/*therapeutic use ; Clinical Laboratory Techniques/*methods ; Clinical Medicine/*methods ; HIV Infections/*diagnosis ; HIV Infections/*drug therapy ; Molecular Diagnostic Techniques/*methods; Female ; Humans ; Infant ; Inpatients ; Malawi ; Male ; Random Allocation |
| Abstract: | Objective: Many African infants fail to receive their diagnostic HIV molecular test results and subsequently, antiretroviral therapy (ART). To determine whether a point-of-care molecular HIV test increases ART access for hospitalized Malawian infants, we simulated a point-of-care test using rapid HIV RNA polymerase chain reaction (Rapid PCR) and compared patient outcomes with an optimized standard care that included assessment with the World Health Organization clinical algorithm for HIV infection plus a DNA PCR with a turnaround time of several weeks (standard care).; Design: Randomized controlled trial.; Methods: Hospitalized HIV-exposed Malawian infants aged |
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| Grant Information: | T32 HL072748-11 United States HL NHLBI NIH HHS; T32 HL072748 United States HL NHLBI NIH HHS; R24 TW007988 United States TW FIC NIH HHS; 5 P30-AI50410 United States AI NIAID NIH HHS; P30 AI050410 United States AI NIAID NIH HHS |
| Substance Nomenclature: | 0 (Anti-Retroviral Agents) |
| Entry Date(s): | Date Created: 20131212 Date Completed: 20140602 Latest Revision: 20211021 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4345126 |
| DOI: | 10.1097/QAI.0000000000000080 |
| PMID: | 24326604 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't