Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes.
| Title: | Amodiaquine-Artesunate versus Artemether-Lumefantrine against Uncomplicated Malaria in Children Less Than 14 Years in Ngaoundere, North Cameroon: Efficacy, Safety, and Baseline Drug Resistant Mutations in pfcrt, pfmdr1, and pfdhfr Genes. |
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| Authors: | Ali IM; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon ; Department of Biochemistry, University of Dschang, BP 67, Dschang, West Region, Cameroon.; Netongo PM; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon.; Atogho-Tiedeu B; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon.; Ngongang EO; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon ; Universite des Montagnes, BP 208, Bangante, West Region, Cameroon.; Ajua A; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon ; Faculty of Science, University of Buea, BP 63, Buea, South West Region, Cameroon.; Achidi EA; Faculty of Science, University of Buea, BP 63, Buea, South West Region, Cameroon.; Mbacham WF; Laboratory for Public Health Research Biotechnologies, University of Yaounde, BP 8094, Yaounde, Centre Region, Cameroon. |
| Source: | Malaria research and treatment [Malar Res Treat] 2013; Vol. 2013, pp. 234683. Date of Electronic Publication: 2013 Dec 15. |
| Publication Type: | Journal Article; Retracted Publication |
| Language: | English |
| Journal Info: | Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101568072 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2090-8075 (Print) Linking ISSN: 20444362 NLM ISO Abbreviation: Malar Res Treat Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Publication: Cairo : Hindawi Publishing Corporation; Original Publication: New York, NY : SAGE-Hindawi, 2010-2019. |
| Abstract: | Background. In Cameroon, both Artesunate-amodiaquine (AS/AQ) and artemether-lumefantrine (AL) are used as first-line treatment against uncomplicated malaria in line with the WHO recommendations. We compared the efficacy and safety of both therapeutic combinations and determined the prevalence of drug resistance conferring mutations in three parasite genes. Methods. One hundred and fifty acute malaria patients between six months and 14 years of age were randomized to receive standard doses of either AS/AQ (73) or AL (77) and followedup for 28 days. Outcome of treatment was according to the standard WHO classification. DNA samples from pretreatment parasite isolates were used to determine the prevalence of resistant mutations in the pfcrt, pfmdr1, and dhfr genes. Results. Both drug combinations induced rapid clearance of parasites and malaria symptoms. PCR-corrected cure rates were 100% and 96.4% for AL. The combinations were well tolerated. Major haplotypes included CVIET (71%), CVMNT (25%) for the pfcrt; SND (100%) for the pfmdr1; IRN (79, 8%), NCS (8.8%), and mixed haplotype (11, 8%) for the dhfr. Conclusion. Both AS/AQ and AL were highly effective and well tolerated for the treatment of uncomplicated falciparum malaria in Ngaoundere, Cameroon. High prevalence of mutant pfcrt alleles confirms earlier observations. Long-term monitoring of safety and efficacy and molecular markers is highly solicited. |
| Comments: | Retraction in: Malar Res Treat. 2019 Jun 20;2019:4274315. doi: 10.1155/2019/4274315.. (PMID: 31321025) |
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| Entry Date(s): | Date Created: 20140124 Date Completed: 20140123 Latest Revision: 20211021 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC3876914 |
| DOI: | 10.1155/2013/234683 |
| PMID: | 24455414 |
| Database: | MEDLINE |
Journal Article; Retracted Publication