[The prognostic value of biochemical indicators under neonatal hepatitis of different etiology].
| Title: | [The prognostic value of biochemical indicators under neonatal hepatitis of different etiology]. |
|---|---|
| Authors: | Alekseeva LA; Bessonova TV; Goriacheva LG; Efremova NA; Rogozina NV; Belova VV |
| Source: | Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2013 Dec (12), pp. 3-7. |
| Publication Type: | English Abstract; Journal Article |
| Language: | Russian |
| Journal Info: | Publisher: Eco-Vector Country of Publication: Russia (Federation) NLM ID: 9432021 Publication Model: Print Cited Medium: Print ISSN: 0869-2084 (Print) Linking ISSN: 08692084 NLM ISO Abbreviation: Klin Lab Diagn Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : Saint-Petersburg, Russia : Eco-Vector; Original Publication: Moskva : "Meditsina", 1992- |
| MeSH Terms: | Prognosis*; C-Reactive Protein/*isolation & purification ; Hepatitis/*blood ; alpha-Macroglobulins/*isolation & purification; Alkaline Phosphatase/blood ; Bilirubin/blood ; C-Reactive Protein/metabolism ; Hepatitis/etiology ; Hepatitis/pathology ; Liver/pathology ; Nitrites/blood ; alpha-Macroglobulins/metabolism ; Child, Preschool ; Humans ; Infant |
| Abstract: | Recently, the share of children with verified neonatal hepatitis induced by genetic predisposition, malformations of biliary tracts, inborn infections with affection of hepatobiliary system increased. The comprehensive biochemical examination of 62 children aged from 1.5 months to 2 years old with diagnosis of neonatal hepatitis. The changes of standard indicators of cytolysis, cholestasis and protein metabolism were on average moderate in group with reliable increase of protein concentration of acute phase of inflammation. The peak changes of biochemical indicators during primary examination are revealed in group of children with malformations of hepatobiliary system conditioned by viruses of herpetic group and in the process of development of expressed fibrosis of liver up to first year of life. The detection of proteins of acute phase makes it possible to objectively evaluate the presence of prolonged inflammatory process in liver and to promote prognosis of course of neonatal hepatitis in children of early age and timely correction of therapy and improvement of outcomes of disease. The detection of C-reactive protein, alpha2-macroglobulin and alpha1-antitripsin is recommended to be included into algorithm of examination of children with neonatal hepatitis. |
| Substance Nomenclature: | 0 (Nitrites); 0 (alpha-Macroglobulins); 9007-41-4 (C-Reactive Protein); EC 3.1.3.1 (Alkaline Phosphatase); RFM9X3LJ49 (Bilirubin) |
| Entry Date(s): | Date Created: 20140425 Date Completed: 20140509 Latest Revision: 20190816 |
| Update Code: | 20260130 |
| PMID: | 24757856 |
| Database: | MEDLINE |
English Abstract; Journal Article