Inhibitory receptor-mediated regulation of natural killer cells.
| Title: | Inhibitory receptor-mediated regulation of natural killer cells. |
|---|---|
| Authors: | Alari-Pahissa E; Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne, Epalinges, Switzerland.; Grandclément C; Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne, Epalinges, Switzerland.; Jeevan-Raj B; Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne, Epalinges, Switzerland.; Held W; Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne, Epalinges, Switzerland. |
| Source: | Critical reviews in immunology [Crit Rev Immunol] 2014; Vol. 34 (6), pp. 455-65. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| Language: | English |
| Journal Info: | Publisher: Begell House Country of Publication: United States NLM ID: 8914819 Publication Model: Print Cited Medium: Internet ISSN: 2162-6472 (Electronic) Linking ISSN: 10408401 NLM ISO Abbreviation: Crit Rev Immunol Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Begell House; Original Publication: Boca Raton, Fla. : CRC Press, c1980- |
| MeSH Terms: | Gene Expression Regulation/*immunology ; Killer Cells, Natural/*immunology ; Receptor Cross-Talk/*immunology ; Receptors, KIR/*immunology; Cytokines/genetics ; Cytokines/immunology ; Cytoplasmic Granules/immunology ; Cytoplasmic Granules/metabolism ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Killer Cells, Natural/cytology ; Receptors, KIR/genetics ; Animals ; Cell Adhesion ; Humans ; Immune Tolerance ; Ligands ; Lymphocyte Activation ; Signal Transduction |
| Abstract: | Natural killer (NK) cells are capable of directly recognizing pathogens, pathogen-infected cells, and transformed cells. NK cells recognize target cells using approximately 100 germ-line encoded receptors, which display activating or inhibitory function. NK cell activation usually requires the engagement of more than one receptor, and these may contribute distinct signaling inputs that are required for the firm adhesion of NK cells to target cells, polarization, and the release of cytotoxic granules, as well as the production of cytokines. In this article we discuss receptor-mediated mechanisms that counteract NK cell activation. The distinct intracellular inhibitory signaling pathways and how they can dominantly interfere with NK cell activation signaling events are discussed first. In addition, mechanisms by which inhibitory receptors modulate cellular activation at the level of receptor-ligand interactions are described. Receptor-mediated inhibition of NK cell function serves three main purposes: ensuring tolerance of NK cells to normal cells, enabling NK cell responses to aberrant host cells that have lost an inhibitory ligand, and, finally, allowing the recognition of certain pathogens that do not express inhibitory ligands. |
| Substance Nomenclature: | 0 (Cytokines); 0 (Histocompatibility Antigens Class I); 0 (Ligands); 0 (Receptors, KIR) |
| Entry Date(s): | Date Created: 20150120 Date Completed: 20150910 Latest Revision: 20191113 |
| Update Code: | 20260130 |
| DOI: | 10.1615/critrevimmunol.2014012220 |
| PMID: | 25597309 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Review