On a model of pattern regeneration based on cell memory.
| Title: | On a model of pattern regeneration based on cell memory. |
|---|---|
| Authors: | Bessonov N; Institute of Problems of Mechanical Engineering, Russian Academy of Sciences, 199178 Saint Petersburg, Russia.; Levin M; Department of Biology, Tufts Center for Regenerative & Developmental Biology, Tufts University, Medford, MA 02155, USA.; Morozova N; Laboratoire Epigénétique et Cancer, CNRS FRE 3377, CEA, 91191 Saclay, France; Institut des Hautes Etudes Scientiques, 91440 Bures-sur-Yvette, France.; Reinberg N; Institute of Problems of Mechanical Engineering, Russian Academy of Sciences, 199178 Saint Petersburg, Russia.; Tosenberger A; Institut des Hautes Etudes Scientiques, 91440 Bures-sur-Yvette, France.; Volpert V; Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622 Villeurbanne, France. |
| Source: | PloS one [PLoS One] 2015 Feb 19; Vol. 10 (2), pp. e0118091. Date of Electronic Publication: 2015 Feb 19 (Print Publication: 2015). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Models, Biological*; Regeneration/*physiology; Signal Transduction |
| Abstract: | We present here a new model of the cellular dynamics that enable regeneration of complex biological morphologies. Biological cell structures are considered as an ensemble of mathematical points on the plane. Each cell produces a signal which propagates in space and is received by other cells. The total signal received by each cell forms a signal distribution defined on the cell structure. This distribution characterizes the geometry of the cell structure. If a part of this structure is removed, the remaining cells have two signals. They keep the value of the signal which they had before the amputation (memory), and they receive a new signal produced after the amputation. Regeneration of the cell structure is stimulated by the difference between the old and the new signals. It is stopped when the two signals coincide. The algorithm of regeneration contains certain rules which are essential for its functioning, being the first quantitative model of cellular memory that implements regeneration of complex patterns to a specific target morphology. Correct regeneration depends on the form and the size of the cell structure, as well as on some parameters of regeneration. |
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| Grant Information: | R01 HD081326 United States HD NICHD NIH HHS; R03 HD081401 United States HD NICHD NIH HHS; 1R01HD081326-01 United States HD NICHD NIH HHS; NIH R03 HD81401-01 United States HD NICHD NIH HHS |
| Entry Date(s): | Date Created: 20150220 Date Completed: 20160101 Latest Revision: 20201217 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4335072 |
| DOI: | 10.1371/journal.pone.0118091 |
| PMID: | 25695252 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.