Impact of the joint association between sex, age and diabetes on long-term mortality after acute myocardial infarction.
| Title: | Impact of the joint association between sex, age and diabetes on long-term mortality after acute myocardial infarction. |
|---|---|
| Authors: | Gao F; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. gao.fei@nhcs.com.sg.; Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore. gao.fei@nhcs.com.sg.; Lam CS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. carolyn_lam@nuhs.edu.sg.; Sim LL; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. sim.ling.ling@nhcs.com.sg.; Koh TH; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. koh.tian.hai@nhcs.com.sg.; Foo D; Cardiac Department, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. david_foo@ttsh.com.sg.; Ong HY; Khoo Teck Puat Hospital, 378 Alexandra Road, Singapore, 159964, Singapore. ong.hean.yee@alexandrahealth.com.sg.; Tong KL; Changi General Hospital, Simei Street 3, Singapore, 529889, Singapore. khim_leng_tong@cgh.com.sg.; Tan HC; National University Heart Centre Singapore, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore. huay_cheem_tan@nuhs.edu.sg.; Machin D; Medical Statistics Group, School of Health and Related Sciences, University of Sheffield, Regents Court, 30 Regent Street, Sheffield, S1 4DA, UK. dm113@leicester.ac.uk.; Department of Cancer Studies and Molecular Medicine, Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, Leicester, LE2 7LX, UK. dm113@leicester.ac.uk.; Wong KS; Singapore General Hospital, 1 Hospital Drive, Singapore, 169608, Singapore. wong.kok.seng@sgh.com.sg.; Chan MY; National University Heart Centre Singapore, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore. mark_chan@nuhs.edu.sg.; Chua TS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. terrance.chua.s.j@nhcs.com.sg. |
| Source: | BMC public health [BMC Public Health] 2015 Mar 31; Vol. 15, pp. 308. Date of Electronic Publication: 2015 Mar 31. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2001- |
| MeSH Terms: | Diabetes Mellitus/*epidemiology ; Myocardial Infarction/*mortality; Myocardial Infarction/epidemiology ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Asian People ; Female ; Hospitalization ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Sex Factors ; Time Factors |
| Abstract: | Background: The role of sex, and its joint effect with age and diabetes mellitus, on mortality subsequent to surviving an acute myocardial infarction (AMI) beyond 30 days are unclear. The high prevalence of diabetes mellitus in an ethnically diverse Asian population motivates this study.; Methods: The study population comprised of a nationwide cohort of Asian patients with AMI, hospitalized between 2000 to 2005, who survived the first 30 days post-admission and were followed prospectively until death or 12 years.; Results: Among the 13,389 survivors, there were fewer women (25.5%) who were older than men (median 70 vs. 58 years) and a larger proportion had diabetes mellitus at admission (51.4% vs. 31.4%). During follow-up 4,707 deaths (women 13.2%; men 22.0%) occurred, with women experiencing higher mortality than men with an averaged hazard ratio (HR): 2.08; 95% confidence interval : 1.96-2.20. However the actual adverse outcome, although always greater, reduced over time with an estimated HR: 2.23 (2.04-2.45) at 30 days to HR: 1.75; (1.47-2.09) 12 years later. The difference in mortality also declined with increasing age: HR 1.80 (1.52-2.13) for those aged 22-59, 1.26 (1.11-1.42) for 60-69, 1.06 (0.96-1.17) and 0.96 (0.85-1.09) for those 70-79 and 80-101 years. Significant two-factor interactions were observed between sex, age and diabetes (P |
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| Entry Date(s): | Date Created: 20150418 Date Completed: 20151120 Latest Revision: 20221207 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4423520 |
| DOI: | 10.1186/s12889-015-1612-x |
| PMID: | 25885528 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't