Circadian Dependence of Infarct Size and Acute Heart Failure in ST Elevation Myocardial Infarction.
| Title: | Circadian Dependence of Infarct Size and Acute Heart Failure in ST Elevation Myocardial Infarction. |
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| Authors: | Seneviratna A; Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore.; Lim GH; National Registry of Diseases Office, (R&SP), Health Promotion Board, Singapore, Singapore.; Devi A; National Registry of Diseases Office, (R&SP), Health Promotion Board, Singapore, Singapore.; Carvalho LP; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Hospital Israelita Albert Einstein, Sao Paolo, Brazil.; Chua T; Department of Cardiology, National Heart Centre, Singapore, Singapore.; Koh TH; Department of Cardiology, National Heart Centre, Singapore, Singapore.; Tan HC; Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore.; Foo D; Department of Cardiology, Tan Tock Seng Hospital, Singapore, Singapore.; Tong KL; Department of Cardiology, Changi General Hospital, Singapore, Singapore.; Ong HY; Department of Cardiology, Khoo Teck Puat Hospital, Singapore, Singapore.; Richards AM; Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Yew CK; National Registry of Diseases Office, (R&SP), Health Promotion Board, Singapore, Singapore.; Chan MY; Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. |
| Source: | PloS one [PLoS One] 2015 Jun 03; Vol. 10 (6), pp. e0128526. Date of Electronic Publication: 2015 Jun 03 (Print Publication: 2015). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| MeSH Terms: | Circadian Rhythm*; Heart Failure/*diagnosis ; Myocardial Infarction/*diagnosis; Biomarkers/blood ; Creatine Kinase, MB Form/blood ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/mortality ; Heart Failure/blood ; Heart Failure/complications ; Heart Failure/mortality ; Myocardial Infarction/blood ; Myocardial Infarction/complications ; Myocardial Infarction/mortality ; Aged ; Diabetes Complications ; Female ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; Photoperiod ; Retrospective Studies ; Severity of Illness Index ; Survival Analysis ; Time Factors ; Tropical Climate |
| Abstract: | Objectives: There are conflicting data on the relationship between the time of symptom onset during the 24-hour cycle (circadian dependence) and infarct size in ST-elevation myocardial infarction (STEMI). Moreover, the impact of this circadian pattern of infarct size on clinical outcomes is unknown. We sought to study the circadian dependence of infarct size and its impact on clinical outcomes in STEMI.; Methods: We studied 6,710 consecutive patients hospitalized for STEMI from 2006 to 2009 in a tropical climate with non-varying day-night cycles. We categorized the time of symptom onset into four 6-hour intervals: midnight-6:00 A.M., 6:00 A.M.-noon, noon-6:00 P.M. and 6:00 P.M.-midnight. We used peak creatine kinase as a surrogate marker of infarct size.; Results: Midnight-6:00 A.M patients had the highest prevalence of diabetes mellitus (P = 0.03), more commonly presented with anterior MI (P = 0.03) and received percutaneous coronary intervention less frequently, as compared with other time intervals (P = 0.03). Adjusted mean peak creatine kinase was highest among midnight-6:00 A.M. patients and lowest among 6:00 A.M.-noon patients (2,590.8±2,839.1 IU/L and 2,336.3±2,386.6 IU/L, respectively, P = 0.04). Midnight-6:00 A.M patients were at greatest risk of acute heart failure (P |
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| Substance Nomenclature: | 0 (Biomarkers); EC 2.7.3.2 (Creatine Kinase, MB Form) |
| Entry Date(s): | Date Created: 20150604 Date Completed: 20160502 Latest Revision: 20181113 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4454698 |
| DOI: | 10.1371/journal.pone.0128526 |
| PMID: | 26039059 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't