Sleep apnea is associated with new-onset atrial fibrillation after coronary artery bypass grafting.
| Title: | Sleep apnea is associated with new-onset atrial fibrillation after coronary artery bypass grafting. |
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| Authors: | Zhao LP; Department of Cardiology, National University Heart Centre Singapore, Singapore.; Kofidis T; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre Singapore, Singapore.; Lim TW; Department of Cardiology, National University Heart Centre Singapore, Singapore.; Chan SP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute, National University Heart Centre Singapore, Singapore; Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia.; Ong TH; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.; Tan HC; Department of Cardiology, National University Heart Centre Singapore, Singapore.; Lee CH; Department of Cardiology, National University Heart Centre Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdclchr@nus.edu.sg. |
| Source: | Journal of critical care [J Crit Care] 2015 Dec; Vol. 30 (6), pp. 1418.e1-5. Date of Electronic Publication: 2015 Jul 09. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8610642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8615 (Electronic) Linking ISSN: 08839441 NLM ISO Abbreviation: J Crit Care Subsets: MEDLINE |
| Imprint Name(s): | Publication: Philadelphia Pa : W.B. Saunders; Original Publication: Orlando, FL : Grune & Stratton, c1986- |
| MeSH Terms: | Atrial Fibrillation/*etiology ; Atrial Fibrillation/*therapy ; Coronary Artery Bypass/*adverse effects ; Sleep Apnea Syndromes/*complications; Aged ; Echocardiography ; Female ; Hospitalization ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Regression Analysis ; Renal Dialysis ; Risk Factors ; Ventricular Remodeling |
| Abstract: | Purpose: New-onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG) remains a prevalent problem. We investigated the relationship between sleep apnea and new-onset post-CABG AF during inhospital stay.; Materials and Methods: We prospectively recruited 171 patients listed for an elective CABG for an overnight sleep study. Sleep apnea was defined as apnea-hypopnea index greater than or equal to 5.; Results: Among the 160 patients who completed the study, those in the sleep apnea group (n=128; 80%) had larger left atrial diameter (40.4±5.4 vs 38.4±6.0 mm; P=.03) and left ventricular end-diastolic dimension (52.6±7.9 vs 49.2±6.8 mm; P=.03) than those in the non-sleep apnea group. The incidence of new-onset post-CABG AF was higher for the sleep apnea than non-sleep apnea groups (24.8% vs 9.7%; P=.07). There was 1 inhospital death and 2 patients with acute renal failure requiring dialysis after CABG in the sleep apnea group. None of the patients developed inhospital stroke. Multiple logistic regression analysis showed that sleep apnea was an independent predictor of post-CABG AF (odds ratio, 4.4; 95% confidence interval, 1.1-18.1; P=.04).; Conclusion: Sleep apnea is prevalent in patients undergoing CABG. It increases the susceptibility to new-onset AF after CABG, probably related to atrial and ventricular remodeling.; (Copyright © 2015 Elsevier Inc. All rights reserved.) |
| Comments: | Comment in: J Crit Care. 2016 Feb;31(1):274-5. doi: 10.1016/j.jcrc.2015.07.018.. (PMID: 26296282); Comment in: J Crit Care. 2016 Feb;31(1):276. doi: 10.1016/j.jcrc.2015.09.027.. (PMID: 26601755); Comment in: J Crit Care. 2016 Feb;31(1):277. doi: 10.1016/j.jcrc.2015.10.006.. (PMID: 26601856) |
| Contributed Indexing: | Keywords: Sleep apnea; arrhythmia; cardiovascular; coronary; predictor; surgery |
| Entry Date(s): | Date Created: 20150804 Date Completed: 20160808 Latest Revision: 20220408 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jcrc.2015.07.002 |
| PMID: | 26235653 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't