Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.
| Title: | Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. |
|---|---|
| Authors: | Jones RM; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Desai C; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Darby TM; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Luo L; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.; Wolfarth AA; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Scharer CD; Department of Immunology and Microbiology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Ardita CS; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Reedy AR; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Keebaugh ES; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Neish AS; Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: aneish@emory.edu. |
| Source: | Cell reports [Cell Rep] 2015 Aug 25; Vol. 12 (8), pp. 1217-25. Date of Electronic Publication: 2015 Aug 13. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| MeSH Terms: | Drosophila/*metabolism ; Intestinal Mucosa/*metabolism ; Lactiplantibacillus plantarum/*metabolism ; Lacticaseibacillus rhamnosus/*metabolism ; NF-E2-Related Factor 2/*metabolism; Drosophila/microbiology ; Intestinal Mucosa/microbiology ; Lactiplantibacillus plantarum/pathogenicity ; Lacticaseibacillus rhamnosus/pathogenicity ; NF-E2-Related Factor 2/genetics ; Animals ; Mice ; Oxidative Stress ; Signal Transduction |
| Abstract: | An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in symbiont-induced host responses have not yet been fully characterized. Here, we report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes. These data show that the xenobiotic-inducible Nrf2 pathway participates as a signaling conduit between the prokaryotic symbiont and the eukaryotic host. Indeed, our data imply that the capacity of lactobacilli to induce redox signaling in epithelial cells is a highly conserved hormetic adaptation to impel cellular conditioning to exogenous biotic stimuli. These data also highlight the role the microbiota plays in eukaryotic cytoprotective pathways and may have significant implications in the characterization of a eubiotic microbiota.; (Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.) |
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| Grant Information: | R01DK071604 United States DK NIDDK NIH HHS; R01DK098391 United States DK NIDDK NIH HHS; R01 DK071604 United States DK NIDDK NIH HHS; R01 DK098391 United States DK NIDDK NIH HHS; R01AI064462 United States AI NIAID NIH HHS; R01 AI064462 United States AI NIAID NIH HHS |
| Substance Nomenclature: | 0 (NF-E2-Related Factor 2) |
| Entry Date(s): | Date Created: 20150818 Date Completed: 20160617 Latest Revision: 20260128 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4640184 |
| DOI: | 10.1016/j.celrep.2015.07.042 |
| PMID: | 26279578 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural