Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.
| Title: | Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. |
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| Authors: | Ramus SJ; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Song H; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Dicks E; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Tyrer JP; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Rosenthal AN; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Intermaggio MP; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Fraser L; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Gentry-Maharaj A; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Hayward J; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Philpott S; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Anderson C; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Edlund CK; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Conti D; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Harrington P; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Barrowdale D; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Bowtell DD; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Alsop K; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Mitchell G; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Cicek MS; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Cunningham JM; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Fridley BL; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Alsop J; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Jimenez-Linan M; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Poblete S; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Lele S; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Sucheston-Campbell L; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Moysich KB; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Sieh W; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; McGuire V; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Lester J; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Bogdanova N; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Dürst M; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Hillemanns P; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Odunsi K; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Whittemore AS; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Karlan BY; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Dörk T; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Goode EL; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Menon U; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Jacobs IJ; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Antoniou AC; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Pharoah PD; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover,; Gayther SA; Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA (SJR, MPI, CKE, DC, SAG); CR-UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (HS, ED, JPT, PH, JA, PDPP); Department of Women's Cancer, UCL EGA Institute for Women's Health, University College London, London, UK (ANR, LF, AGM, JH, SP, CA, UM, IJJ); Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK (DB, ACA); Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (DDB, KA, GM, AOCSSG); Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria, Australia (DDB); Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (DDB, GM); Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK (DDB); Westmead Millennium Institute, Westmead Hospital, Sydney, Australia (AOCSSG); The QIMR Berghofer Medical Research Institute, Brisbane, Australia (AOCSSG); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (MSC, JMC, ELG); Department of Biostatistics, University of Kansas Medical Center, Andover, KS (BLF); Department of Histopathology, Addenbrooke's Hospital, Cambridge, UK (MJL); Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, NY (SP, SL, KO); Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY (LSC, KBM); Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, CA (WS, VM, ASW); Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center (JL, BYK); Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (NB, TD); Radiation Oncology Research Unit, Hannover Medical School, Hannover, |
| Corporate Authors: | AOCS Study Group; Ovarian Cancer Association Consortium |
| Source: | Journal of the National Cancer Institute [J Natl Cancer Inst] 2015 Aug 27; Vol. 107 (11). Date of Electronic Publication: 2015 Aug 27 (Print Publication: 2015). |
| Publication Type: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 7503089 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1460-2105 (Electronic) Linking ISSN: 00278874 NLM ISO Abbreviation: J Natl Cancer Inst Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Cary, NC : Oxford University Press; Original Publication: Bethesda, Md., U. S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health; Washington, for sale by the Supt. of Docs., U. S. Govt. Print. Off. |
| MeSH Terms: | Germ-Line Mutation*; Cell Cycle Proteins/*genetics ; DNA-Binding Proteins/*genetics ; Neoplasms, Glandular and Epithelial/*genetics ; Nuclear Proteins/*genetics ; Ovarian Neoplasms/*genetics ; RNA Helicases/*genetics ; Tumor Suppressor Proteins/*genetics ; Ubiquitin-Protein Ligases/*genetics; Neoplasms, Glandular and Epithelial/mortality ; Ovarian Neoplasms/mortality ; United States/epidemiology ; Adult ; Aged ; Carcinoma, Ovarian Epithelial ; Fanconi Anemia Complementation Group N Protein ; Fanconi Anemia Complementation Group Proteins ; Female ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Middle Aged ; Mutation, Missense ; Predictive Value of Tests ; Risk ; White People |
| Abstract: | Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, responsible for 13 000 deaths per year in the United States. Risk prediction based on identifying germline mutations in ovarian cancer susceptibility genes could have a clinically significant impact on reducing disease mortality.; Methods: Next generation sequencing was used to identify germline mutations in the coding regions of four candidate susceptibility genes-BRIP1, BARD1, PALB2 and NBN-in 3236 invasive EOC case patients and 3431 control patients of European origin, and in 2000 unaffected high-risk women from a clinical screening trial of ovarian cancer (UKFOCSS). For each gene, we estimated the prevalence and EOC risks and evaluated associations between germline variant status and clinical and epidemiological risk factor information. All statistical tests were two-sided.; Results: We found an increased frequency of deleterious mutations in BRIP1 in case patients (0.9%) and in the UKFOCSS participants (0.6%) compared with control patients (0.09%) (P = 1 x 10(-4) and 8 x 10(-4), respectively), but no differences for BARD1 (P = .39), NBN1 ( P = .61), or PALB2 (P = .08). There was also a difference in the frequency of rare missense variants in BRIP1 between case patients and control patients (P = 5.5 x 10(-4)). The relative risks associated with BRIP1 mutations were 11.22 for invasive EOC (95% confidence interval [CI] = 3.22 to 34.10, P = 1 x 10(-4)) and 14.09 for high-grade serous disease (95% CI = 4.04 to 45.02, P = 2 x 10(-5)). Segregation analysis in families estimated the average relative risks in BRIP1 mutation carriers compared with the general population to be 3.41 (95% CI = 2.12 to 5.54, P = 7×10(-7)).; Conclusions: Deleterious germline mutations in BRIP1 are associated with a moderate increase in EOC risk. These data have clinical implications for risk prediction and prevention approaches for ovarian cancer and emphasize the critical need for risk estimates based on very large sample sizes before genes of moderate penetrance have clinical utility in cancer prevention.; (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.) |
| Comments: | Comment in: J Natl Cancer Inst. 2015 Aug 27;107(11):djv262. doi: 10.1093/jnci/djv262.. (PMID: 26315355) |
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| Grant Information: | P30 CA016056 United States CA NCI NIH HHS; C1005/A12677 United Kingdom CRUK_ Cancer Research UK; C1005/A7749 United Kingdom CRUK_ Cancer Research UK; C490/A10124 United Kingdom CRUK_ Cancer Research UK; 12677 United Kingdom CRUK_ Cancer Research UK; R01CA086381 United States CA NCI NIH HHS; R01CA122443 United States CA NCI NIH HHS; C1005/A6383 United Kingdom CRUK_ Cancer Research UK; P50CA136393 United States CA NCI NIH HHS; P50 CA136393 United States CA NCI NIH HHS; P30-CA15083 United States CA NCI NIH HHS; R01CA152990 United States CA NCI NIH HHS; P50 CA159981 United States CA NCI NIH HHS; R01CA61107 United States CA NCI NIH HHS; 11174 United Kingdom CRUK_ Cancer Research UK; C490/A10119 United Kingdom CRUK_ Cancer Research UK; U01 CA086381 United States CA NCI NIH HHS; P50CA159981 United States CA NCI NIH HHS; C315/A2621 United Kingdom CRUK_ Cancer Research UK; R01CA178535 United States CA NCI NIH HHS; P30CA014089 United States CA NCI NIH HHS; R01 CA178535 United States CA NCI NIH HHS; C490/A16561 United Kingdom CRUK_ Cancer Research UK; U01 CA152990 United States CA NCI NIH HHS; P30 CA014089 United States CA NCI NIH HHS; R01 CA122443 United States CA NCI NIH HHS; P30 CA015083 United States CA NCI NIH HHS; 16561 United Kingdom CRUK_ Cancer Research UK; 10124 United Kingdom CRUK_ Cancer Research UK |
| Substance Nomenclature: | 0 (Cell Cycle Proteins); 0 (DNA-Binding Proteins); 0 (Fanconi Anemia Complementation Group N Protein); 0 (Fanconi Anemia Complementation Group Proteins); 0 (NBN protein, human); 0 (Nuclear Proteins); 0 (PALB2 protein, human); 0 (Tumor Suppressor Proteins); EC 2.3.2.27 (BARD1 protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 3.6.4.13 (BRIP1 protein, human); EC 3.6.4.13 (RNA Helicases) |
| Entry Date(s): | Date Created: 20150829 Date Completed: 20151106 Latest Revision: 20251027 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4643629 |
| DOI: | 10.1093/jnci/djv214 |
| PMID: | 26315354 |
| Database: | MEDLINE |
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.