Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats.
| Title: | Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats. |
|---|---|
| Authors: | Marcos AB; 1 Programa de Pós-Graduação em Ciências Médicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Forner S; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Martini AC; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Patrício ES; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Clarke JR; 3 Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro, RJ, Brazil .; Costa R; 3 Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro, RJ, Brazil .; Felix-Alves J; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Vieira VJ; 1 Programa de Pós-Graduação em Ciências Médicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; de Andrade EL; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Mazzuco TL; 4 Departamento de Clínica Médica, Centro de Ciências da Saúde, Universidade Estadual de Londrina , PR, Brazil .; Calixto JB; 2 Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, SC, Brazil .; Figueiredo CP; 3 Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro, RJ, Brazil . |
| Source: | Journal of neurotrauma [J Neurotrauma] 2016 Feb 01; Vol. 33 (3), pp. 261-8. Date of Electronic Publication: 2015 Dec 23. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9042 (Electronic) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| Imprint Name(s): | Publication: Larchmont, NY : Mary Ann Liebert; Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| MeSH Terms: | Gastric Inhibitory Polypeptide/*metabolism ; Neurogenesis/*physiology ; Receptors, Gastrointestinal Hormone/*metabolism ; Spinal Cord Injuries/*metabolism; Behavior, Animal/physiology ; Motor Activity/physiology ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Animals ; Disease Models, Animal ; Male ; Rats ; Rats, Wistar |
| Abstract: | Spinal cord injury (SCI) results in loss of movement, sensibility, and autonomic control at the level of the lesion and at lower parts of the body. Several experimental strategies have been used in attempts to increase endogenous mechanisms of neuroprotection, neuroplasticity, and repair, but with limited success. It is known that glucose-dependent insulinotropic peptide (GIP) and its receptor (GIPR) can enhance synaptic plasticity, neurogenesis, and axonal outgrowth. However, their role in the injury has never been studied. The aim of this study was to evaluate the changes in expression levels of both GIP and GIPR in acute and chronic phases of SCI in rats. Following SCI (2 to 24 h after damage), the rat spinal cord showed a lesion in which the epicenter had a cavity with hemorrhage and necrosis. Furthermore, the lesion cavity also showed ballooned cells 14 and 28 days after injury. We found that SCI induced increases in GIPR expression in areas neighboring the site of injury at 6 h and 28 days after the injury. Moreover, higher GIP expression was observed in these regions on day 28. Neuronal projections from the injury epicenter showed an increase in GIP immunoreactivity 24 h and 14 and 28 days after SCI. Interestingly, GIP was also found in progenitor cells at the spinal cord canal 24 h after injury, whereas both GIP and GIPR were present in progenitor cells at the injury epicenter 14 days after in SCI animals. These results suggest that GIP and its receptor might be implicated with neurogenesis and the repair process after SCI. |
| References: | Behav Brain Res. 2013 May 15;245:96-100. (PMID: 23439217); Amino Acids. 2000;19(1):351-61. (PMID: 11026506); J Neurosci. 2001 May 15;21(10):3392-400. (PMID: 11331369); Acta Neurochir Suppl. 2000;76:291-6. (PMID: 11450028); Biochem Soc Trans. 2001 Aug;29(Pt 4):513-25. (PMID: 11498020); Nature. 2001 Dec 13;414(6865):799-806. (PMID: 11742412); J Neurotrauma. 2001 Dec;18(12):1399-407. (PMID: 11780869); Spine (Phila Pa 1976). 2002 Jul 15;27(14):1504-10. (PMID: 12131708); Mol Cell Neurosci. 2002 Nov;21(3):421-35. (PMID: 12498784); Nat Rev Neurosci. 2004 Feb;5(2):146-56. (PMID: 14735117); Curr Stem Cell Res Ther. 2013 Jan;8(1):25-38. (PMID: 23270635); Spine J. 2004 Jul-Aug;4(4):451-64. (PMID: 15246307); Hippocampus. 2014 Feb;24(2):239-48. (PMID: 24123782); Endocrinology. 1993 Dec;133(6):2861-70. (PMID: 8243312); J Neurotrauma. 1995 Feb;12(1):1-21. (PMID: 7783230); Neuron. 1997 Jul;19(1):197-203. (PMID: 9247275); J Neurosci Res. 1997 Oct 15;50(2):337-44. (PMID: 9373042); J Neurosci. 1998 Jul 15;18(14):5354-65. (PMID: 9651218); J Neurosci. 2005 Feb 16;25(7):1816-25. (PMID: 15716418); Annu Rev Neurosci. 2005;28:223-50. (PMID: 16022595); J Neurotrauma. 2006 Mar-Apr;23(3-4):521-36. (PMID: 16629634); Nat Rev Neurosci. 2006 Aug;7(8):628-43. (PMID: 16858391); Nat Neurosci. 2006 Nov;9(11):1371-81. (PMID: 17057708); J Neurosci Res. 2007 Aug 1;85(10):2099-119. (PMID: 17510976); J Neurochem. 2007 Sep;102(5):1459-65. (PMID: 17697047); J Neurotrauma. 2007 Sep;24(9):1502-12. (PMID: 17892411); FASEB J. 2008 Jan;22(1):246-60. (PMID: 17720802); J Neurophysiol. 2008 Apr;99(4):1590-5. (PMID: 18234983); Endocr Rev. 2008 May;29(3):367-79. (PMID: 18292465); PLoS Biol. 2008 Jul 22;6(7):e182. (PMID: 18651793); Physiology (Bethesda). 2008 Oct;23:296-304. (PMID: 18927205); Nat Rev Neurosci. 2008 Nov;9(11):839-55. (PMID: 18931697); Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. (PMID: 19188609); J Neurosci Res. 2009 Jun;87(8):1858-70. (PMID: 19170165); Cell Mol Neurobiol. 2009 Sep;29(6-7):999-1013. (PMID: 19350385); J Clin Invest. 2010 Jan;120(1):29-40. (PMID: 20051634); J Neurochem. 2010 Feb;112(3):762-72. (PMID: 19925583); Behav Pharmacol. 2010 Sep;21(5-6):394-408. (PMID: 20574409); Endocrinology. 2011 Feb;152(2):436-46. (PMID: 21159855); Peptides. 2011 Apr;32(4):781-9. (PMID: 21185343); J Alzheimers Dis. 2011;24(1):61-75. (PMID: 21157027); J Neurophysiol. 2011 Apr;105(4):1574-80. (PMID: 21273318); Acta Neurobiol Exp (Wars). 2011;71(2):281-99. (PMID: 21731081); Brain Res. 2011 Sep 30;1415:23-33. (PMID: 21885039); Eur J Pharmacol. 2012 Jan 15;674(2-3):294-306. (PMID: 22115896); Neuroscience. 2014 Apr 18;265:302-12. (PMID: 24508749); Neurosurgery. 2014 Aug;61 Suppl 1:36-42. (PMID: 25032529); J Neurosci. 2014 Sep 17;34(38):12788-800. (PMID: 25232115); J Neurosci. 2014 Nov 12;34(46):15347-55. (PMID: 25392502); Neurobiol Dis. 2015 Jan;73:36-48. (PMID: 25220840); J Neurosci. 2014 Dec 3;34(49):16369-84. (PMID: 25471575); Spinal Cord. 2015 Jan;53(1):14-8. (PMID: 25366531); Cell Stress Chaperones. 2015 Mar;20(2):237-51. (PMID: 25527070); Brain Res. 2015 Feb 19;1598:76-87. (PMID: 25511995); Cold Spring Harb Perspect Biol. 2015 Mar;7(3):a020602. (PMID: 25475091); Int J Clin Pract. 2015 May;69(5):531-49. (PMID: 25363540); Curr Stem Cell Res Ther. 2015;10(2):132-9. (PMID: 25266982); Neuropharmacology. 2015 Sep;96(Pt A):113-23. (PMID: 25445484); Prog Neurobiol. 1991;36(5):343-62. (PMID: 1887067) |
| Contributed Indexing: | Keywords: glucose-dependent insulinotropic peptide (GIP); glucose-dependent insulinotropic peptide receptor (GIPR); nestin-positive cells; spinal cord injury (SCI) |
| Substance Nomenclature: | 0 (Receptors, Gastrointestinal Hormone); 59392-49-3 (Gastric Inhibitory Polypeptide); D6H00MV7K8 (gastric inhibitory polypeptide receptor) |
| Entry Date(s): | Date Created: 20151001 Date Completed: 20161031 Latest Revision: 20181113 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4744885 |
| DOI: | 10.1089/neu.2015.3877 |
| PMID: | 26421658 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't