Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study.
| Title: | Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study. |
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| Authors: | Hill TR; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Tom.Hill@ncl.ac.uk.; School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. Tom.Hill@ncl.ac.uk.; Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. Tom.Hill@ncl.ac.uk.; Granic A; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Institute for Health and Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.; Davies K; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Institute for Health and Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.; Collerton J; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Martin-Ruiz C; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.; Siervo M; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.; Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Mathers JC; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.; Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Adamson AJ; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.; Institute for Health and Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK.; Francis RM; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Pearce SH; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.; Razvi S; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.; Kirkwood TBL; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Jagger C; Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Institute for Health and Society, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK. |
| Source: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2016 Mar; Vol. 27 (3), pp. 1199-1208. Date of Electronic Publication: 2015 Oct 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Springer International Country of Publication: England NLM ID: 9100105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-2965 (Electronic) Linking ISSN: 0937941X NLM ISO Abbreviation: Osteoporos Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, UK : Springer International, c1990- |
| MeSH Terms: | Vitamin D/*analogs & derivatives ; Vitamin D Deficiency/*epidemiology; Blood Specimen Collection/methods ; Calcium, Dietary/administration & dosage ; Diet/statistics & numerical data ; England/epidemiology ; Exercise/physiology ; Vitamin D/administration & dosage ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/etiology ; Aged, 80 and over ; Dietary Supplements ; Female ; Humans ; Longitudinal Studies ; Male ; Prevalence ; Residence Characteristics ; Risk Factors ; Seasons |
| Abstract: | Summary: Data on vitamin D status in very old adults are lacking. The aim of this study was to assess 25-hydroxyvitamin D [25(OH)D] concentrations and its predictors in 775 adults aged 85 years old living in North-East England. Low 25(OH)D was alarmingly high during winter/spring months, but its biological significance is unknown.; Introduction: Despite recent concerns about the high prevalence of vitamin D deficiency in much of the British adult and paediatric population, there is a dearth of data on vitamin D status and its predictors in very old adults. The objective of the present study was to describe vitamin D status and its associated factors in a broadly representative sample of very old men and women aged 85 years living in the North East of England (55° N).; Methods: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were analysed in 775 participants in the baseline phase of the Newcastle 85+ cohort study. Season of blood sampling, dietary, health, lifestyle and anthropometric data were collected and included as potential predictors of vitamin D status in ordinal regression models.; Results: Median serum 25(OH)D concentrations were 27, 45, 43 and 33 nmol/L during spring, summer, autumn and winter, respectively. The prevalence of vitamin D deficiency according to North American Institute of Medicine guidelines [serum 25(OH)D |
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| Grant Information: | United Kingdom BHF_ British Heart Foundation; G0500783 United Kingdom MRC_ Medical Research Council; United Kingdom BB_ Biotechnology and Biological Sciences Research Council; G0700718 United Kingdom MRC_ Medical Research Council; NIHR-RP-02-12-001 United Kingdom DH_ Department of Health; MR/K006312/1 United Kingdom MRC_ Medical Research Council; MR/K02325X/1 United Kingdom MRC_ Medical Research Council; MR/L016354/1 United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Keywords: Aged 80 and over; Determinants; Newcastle 85+ cohort study; Serum 25-hydroxyvitamin D |
| Substance Nomenclature: | 0 (Calcium, Dietary); 1406-16-2 (Vitamin D); A288AR3C9H (25-hydroxyvitamin D) |
| Entry Date(s): | Date Created: 20151016 Date Completed: 20161213 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s00198-015-3366-9 |
| PMID: | 26468040 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't