Autophagic degradation of peroxisomes in mammals.
| Title: | Autophagic degradation of peroxisomes in mammals. |
|---|---|
| Authors: | Zientara-Rytter K; Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA 92093-0322, U.S.A.; Subramani S; Section of Molecular Biology, Division of Biological Sciences, University California, San Diego, CA 92093-0322, U.S.A. ssubramani@ucsd.edu. |
| Source: | Biochemical Society transactions [Biochem Soc Trans] 2016 Apr 15; Vol. 44 (2), pp. 431-40. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Review |
| Language: | English |
| Journal Info: | Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Portland Press On The Behalf Of The Biochemical Society |
| MeSH Terms: | Autophagy*; Peroxisomes/*metabolism; Animals ; Humans ; Mammals ; Models, Biological |
| Abstract: | Peroxisomes are essential organelles required for proper cell function in all eukaryotic organisms. They participate in a wide range of cellular processes including the metabolism of lipids and generation, as well as detoxification, of hydrogen peroxide (H2O2). Therefore, peroxisome homoeostasis, manifested by the precise and efficient control of peroxisome number and functionality, must be tightly regulated in response to environmental changes. Due to the existence of many physiological disorders and diseases associated with peroxisome homoeostasis imbalance, the dynamics of peroxisomes have been widely examined. The increasing volume of reports demonstrating significant involvement of the autophagy machinery in peroxisome removal leads us to summarize current knowledge of peroxisome degradation in mammalian cells. In this review we present current models of peroxisome degradation. We particularly focus on pexophagy-the selective clearance of peroxisomes through autophagy. We also critically discuss concepts of peroxisome recognition for pexophagy, including signalling and selectivity factors. Finally, we present examples of the pathological effects of pexophagy dysfunction and suggest promising future directions.; (© 2016 Authors; published by Portland Press Limited.) |
| References: | Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10146-51. (PMID: 9707615); Genome Res. 2013 Feb;23(2):236-47. (PMID: 23105016); Res Microbiol. 2006 Oct;157(8):701-13. (PMID: 16854568); J Cell Sci. 2011 Jan 15;124(Pt 2):161-70. (PMID: 21187343); Nat Cell Biol. 2015 Oct;17(10):1259-1269. (PMID: 26344566); Autophagy. 2013 Dec;9(12):1955-64. (PMID: 24128730); Acta Histochem. 2010 Jul;112(4):364-71. (PMID: 19500819); Nat Cell Biol. 2009 Jan;11(1):65-70. (PMID: 19079246); Physiol Rev. 1966 Apr;46(2):323-57. (PMID: 5325972); Dev Cell. 2008 Mar;14(3):365-76. (PMID: 18331717); J Cell Biol. 2009 Oct 19;187(2):265-77. (PMID: 19822672); J Biol Chem. 2006 Feb 17;281(7):4035-41. (PMID: 16332691); Mol Cell. 2009 Feb 27;33(4):505-16. (PMID: 19250911); Autophagy. 2014 Mar;10(3):518-9. (PMID: 24413187); Biochimie. 2014 Mar;98:16-28. (PMID: 24345375); J Cell Biol. 1966 Aug;30(2):442-50. (PMID: 5968981); Mol Cell. 2007 Apr 13;26(1):1-14. (PMID: 17434122); Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20567-74. (PMID: 19074260); Mol Cell Biol. 2002 Jun;22(12):4358-65. (PMID: 12024045); Curr Opin Cell Biol. 2010 Apr;22(2):124-31. (PMID: 20034776); J Cell Biol. 2014 Feb 17;204(4):541-57. (PMID: 24535825); Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2100-5. (PMID: 10978255); Plant Cell. 2013 Oct;25(10):4085-100. (PMID: 24179123); Science. 2003 Apr 18;300(5618):445-52. (PMID: 12702867); Autophagy. 2014 Jul;10(7):1348-9. (PMID: 24905344); J Cell Sci. 2013 Feb 15;126(Pt 4):939-52. (PMID: 23239026); J Histochem Cytochem. 2001 May;49(5):613-22. (PMID: 11304799); Eur J Cell Biol. 1993 Jun;61(1):67-80. (PMID: 8223709); Autophagy. 2015;11(8):1326-40. (PMID: 26086376); Plant Cell Physiol. 2007 Jun;48(6):881-5. (PMID: 17478548); Cell. 2010 Mar 19;140(6):951-951.e2. (PMID: 20303882); J Biol Chem. 2004 Jan 2;279(1):421-8. (PMID: 14561759); Science. 2010 Oct 22;330(6003):517-21. (PMID: 20966255); Traffic. 2009 Nov;10(11):1722-33. (PMID: 19719477); Front Physiol. 2012 Jul 17;3:283. (PMID: 22936916); Cell Cycle. 2009 Jul 1;8(13):1986-90. (PMID: 19502794); Nat Cell Biol. 2011 Feb;13(2):132-41. (PMID: 21258367); EMBO Rep. 2014 Aug;15(8):862-70. (PMID: 24968893); Mol Biol Cell. 2002 Dec;13(12):4243-55. (PMID: 12475949); Cell. 2007 Dec 14;131(6):1149-63. (PMID: 18083104); Cold Spring Harb Symp Quant Biol. 2000;65:521-6. (PMID: 12760069); Biochim Biophys Acta. 2012 Sep;1822(9):1363-73. (PMID: 22178243); FEBS Lett. 2014 Nov 3;588(21):3862-9. (PMID: 25281559); World J Biol Chem. 2012 May 26;3(5):93-7. (PMID: 22649571); Mol Cell Biol. 2010 Dec;30(24):5672-85. (PMID: 20937771); J Biol Chem. 1999 Nov 26;274(48):34277-82. (PMID: 10567403); Biochim Biophys Acta. 2012 Sep;1822(9):1358-62. (PMID: 22497955); Int J Cell Biol. 2012;2012:673290. (PMID: 22536250); J Cell Biol. 1969 May;41(2):521-35. (PMID: 4389026); Int J Cell Biol. 2012;2012:189794. (PMID: 22536246); Toxicol Rev. 2004;23(1):51-7. (PMID: 15298493); J Biol Chem. 2010 Apr 23;285(17):13045-56. (PMID: 20139070); FEBS Lett. 2014 Mar 3;588(5):822-8. (PMID: 24492006); Nature. 1980 Jan 24;283(5745):397-8. (PMID: 6766207); J Biochem. 2008 May;143(5):649-60. (PMID: 18281296); FEBS Lett. 1975 Dec 1;60(1):149-52. (PMID: 6318); Anat Rec. 1997 Apr;247(4):449-54. (PMID: 9096783); Cell. 2010 May 14;141(4):668-81. (PMID: 20451243); Diabetes. 2011 Jan;60(1):200-8. (PMID: 20971967); Eur J Cell Biol. 1993 Dec;62(2):372-83. (PMID: 7925493); J Cell Biol. 1969 May;41(2):536-46. (PMID: 5783872); Science. 2011 Jul 8;333(6039):228-33. (PMID: 21617041); Cell Res. 2014 Jan;24(1):24-41. (PMID: 24366339); Nat Cell Biol. 2015 Nov;17(11):1371-3. (PMID: 26458245); Diabetes. 2012 Mar;61(3):728-38. (PMID: 22315314); J Biol Chem. 2014 May 16;289(20):14089-108. (PMID: 24662292); Nat Cell Biol. 2010 Feb;12(2):119-31. (PMID: 20098416); Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210. (PMID: 23847781); FEBS Lett. 1992 Jun 8;304(1):93-7. (PMID: 1618306); Autophagy. 2012 Nov;8(11):1680-1. (PMID: 22874561); Antioxid Redox Signal. 2013 Jul 20;19(3):211-30. (PMID: 23088293); Genes Cells. 2015 Jan;20(1):36-49. (PMID: 25358256); Exp Cell Res. 1982 Jan;137(1):191-201. (PMID: 7056284); Am J Respir Crit Care Med. 2009 Apr 15;179(8):694-704. (PMID: 19151196); Cell. 2012 Feb 3;148(3):399-408. (PMID: 22304911); Mol Cell Biol. 2011 Aug;31(15):3082-4. (PMID: 21628530); Nature. 1998 Sep 24;395(6700):392-5. (PMID: 9759730); EMBO Rep. 2013 May;14(5):441-9. (PMID: 23559066); J Biol Chem. 1962 Nov;237:3468-75. (PMID: 13986151); Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14590-5. (PMID: 21844353); Exp Cell Res. 2008 Nov 15;314(19):3531-41. (PMID: 18848543); Cell Death Dis. 2011 Oct 06;2:e213. (PMID: 21975295); J Cell Biol. 2014 Oct 13;207(1):91-105. (PMID: 25287303); Mol Cell. 2010 Nov 24;40(4):509-20. (PMID: 21095582); Science. 1975 Nov 21;190(4216):787-9. (PMID: 1198095); J Lipid Res. 2010 Oct;51(10):2863-95. (PMID: 20558530); Autophagy. 2013 Mar;9(3):442-4. (PMID: 23328407); Science. 1996 Jul 26;273(5274):501-3. (PMID: 8662539); Nat Cell Biol. 2010 Sep;12(9):814-22. (PMID: 20811353); Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4561-6. (PMID: 19246395); Autophagy. 2009 Jul;5(5):732-3. (PMID: 19398892); Circulation. 2004 Oct 5;110(14):2024-31. (PMID: 15451785); Nat Cell Biol. 2013 Oct;15(10):1186-96. (PMID: 23955302); Biochim Biophys Acta. 2012 Sep;1822(9):1326-36. (PMID: 22617146); Cell Cycle. 2010 Dec 15;9(24):4805-11. (PMID: 21150274); J Cell Biol. 1975 Nov;67(2PT.1):281-309. (PMID: 406); EMBO J. 2012 Jun 29;31(13):2852-68. (PMID: 22643220); J Cell Biol. 2008 Mar 24;180(6):1065-71. (PMID: 18347073); J Biol Chem. 2013 Jan 11;288(2):1099-113. (PMID: 23209295); Nat Cell Biol. 2009 Oct;11(10):1233-40. (PMID: 19749745); Nat Rev Mol Cell Biol. 2014 Jan;15(1):65-74. (PMID: 24326622); Nat Cell Biol. 2013 Jul;15(7):741-50. (PMID: 23685627); J Biol Chem. 2014 Mar 28;289(13):8735-41. (PMID: 24515117); Cell Death Differ. 2001 Aug;8(8):776-84. (PMID: 11526430); Cell Metab. 2014 Nov 4;20(5):882-897. (PMID: 25440060); Autophagy. 2014 Sep;10(9):1549-64. (PMID: 25007327); Annu Rev Cell Biol. 1985;1:489-530. (PMID: 3916321); Biochim Biophys Acta. 2016 May;1863(5):1061-9. (PMID: 26384874); DNA Cell Biol. 2000 Feb;19(2):113-20. (PMID: 10701777); Cell Res. 2014 Jan;24(1):92-104. (PMID: 24281265); Redox Biol. 2015;4:40-7. (PMID: 25498966); Histochem Cell Biol. 2008 Jan;129(1):73-83. (PMID: 17929048); FEBS Lett. 2011 Jun 6;585(11):1625-39. (PMID: 21570395); Curr Opin Cell Biol. 2012 Aug;24(4):484-9. (PMID: 22683191); J Biol Chem. 2015 Mar 27;290(13):8623-31. (PMID: 25694426); Ann N Y Acad Sci. 1982;386:111-35. (PMID: 6953842); Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4153-8. (PMID: 20160076) |
| Grant Information: | R01 DK041737 United States DK NIDDK NIH HHS; R37 DK041737 United States DK NIDDK NIH HHS; R56 DK041737 United States DK NIDDK NIH HHS; DK41737 United States DK NIDDK NIH HHS |
| Contributed Indexing: | Keywords: autophagy; peroxisome; pexophagy; pexophagy receptor/adaptor |
| Entry Date(s): | Date Created: 20160413 Date Completed: 20161230 Latest Revision: 20240610 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4958620 |
| DOI: | 10.1042/BST20150268 |
| PMID: | 27068951 |
| Database: | MEDLINE |
Journal Article; Research Support, N.I.H., Extramural; Review