The role of natural polyphenols in cell signaling and cytoprotection against cancer development.
| Title: | The role of natural polyphenols in cell signaling and cytoprotection against cancer development. |
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| Authors: | Lewandowska H; Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland. Electronic address: h.lewandowska@ichtj.waw.pl.; Kalinowska M; Division of Chemistry, Bialystok University of Technology, Zamenhofa 29, 15-435 Bialystok, Poland.; Lewandowski W; Division of Chemistry, Bialystok University of Technology, Zamenhofa 29, 15-435 Bialystok, Poland.; Stępkowski TM; Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland.; Brzóska K; Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Dorodna 16, 03-195 Warsaw, Poland. |
| Source: | The Journal of nutritional biochemistry [J Nutr Biochem] 2016 Jun; Vol. 32, pp. 1-19. Date of Electronic Publication: 2015 Nov 24. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE |
| Imprint Name(s): | Publication: : New York, NY : Elsevier Science; Original Publication: Stoneham, MA, USA : Butterworths, c1990- |
| MeSH Terms: | Diet, Healthy* ; Models, Biological* ; Signal Transduction*; Anticarcinogenic Agents/*therapeutic use ; Cinnamates/*therapeutic use ; Flavonoids/*therapeutic use ; Neoplasms/*prevention & control; Angiogenesis Inhibitors/metabolism ; Angiogenesis Inhibitors/therapeutic use ; Anticarcinogenic Agents/metabolism ; Cinnamates/metabolism ; Flavonoids/metabolism ; Free Radical Scavengers/metabolism ; Free Radical Scavengers/therapeutic use ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/prevention & control ; Neoplasm Metastasis/therapy ; Neoplasms/diet therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic/diet therapy ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/prevention & control ; Polyphenols/metabolism ; Polyphenols/therapeutic use ; Precancerous Conditions/diet therapy ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology ; Precancerous Conditions/prevention & control ; Animals ; Apoptosis ; Autophagy ; Carcinogenesis ; Epigenesis, Genetic ; Humans |
| Abstract: | The cytoprotective and anticancer action of dietary in-taken natural polyphenols has for long been attributed only to their direct radical scavenging activities. Currently it is well supported that those compounds display a broad spectrum of biological and pharmacological outcomes mediated by their complex metabolism, interaction with gut microbiota as well as direct interactions of their metabolites with key cellular signaling proteins. The beneficial effects of natural polyphenols and their synthetic derivatives are extensively studied in context of cancer prophylaxis and therapy. Herein we focus on cell signaling to explain the beneficial role of polyphenols at the three stages of cancer development: we review the recent proceedings about the impact of polyphenols on the cytoprotective antioxidant response and their proapoptotic action at the premalignant stage, and finally we present data showing how phenolic acids (e.g., caffeic, chlorogenic acids) and flavonols (e.g., quercetin) hamper the development of metastatic cancer.; (Copyright © 2015 Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: Anticancer; Antioxidant; Caffeic acid; Chlorogenic acid; Phenolic compounds; Quercetin |
| Substance Nomenclature: | 0 (Angiogenesis Inhibitors); 0 (Anticarcinogenic Agents); 0 (Cinnamates); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Polyphenols) |
| Entry Date(s): | Date Created: 20160505 Date Completed: 20171009 Latest Revision: 20191210 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.jnutbio.2015.11.006 |
| PMID: | 27142731 |
| Database: | MEDLINE |
Journal Article; Review