Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population.
| Title: | Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population. |
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| Authors: | Kallel A; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia.; Sbaï MH; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia.; Sédiri Y; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia.; Feki M; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia.; Mourali MS; Hôpital la Rabta, Service des Explorations Fonctionnelles et de Reanimations en Cardiologie, Université de Tunis El Manar, Tunis, Tunisia.; Mechmeche R; Hôpital la Rabta, Service des Explorations Fonctionnelles et de Reanimations en Cardiologie, Université de Tunis El Manar, Tunis, Tunisia.; Jemaa R; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia. jemaa_riadh@yahoo.fr.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia. jemaa_riadh@yahoo.fr.; Kaabachi N; Faculté de Medicine de Tunis, Université de Tunis El Manar, 1007, Tunis, Tunisia.; Hôpital la Rabta, Service de Biochimie, Université de Tunis El Manar, LR99ES11, 1007, Tunis, Tunisia. |
| Source: | Biochemical genetics [Biochem Genet] 2016 Oct; Vol. 54 (5), pp. 653-64. Date of Electronic Publication: 2016 Jun 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : New York : Kluwer Academic/Plenum Publishers; Original Publication: New York, Plenum Press. |
| MeSH Terms: | Polymorphism, Single Nucleotide*; Myocardial Infarction/*genetics ; Prothrombin/*genetics ; White People/*genetics; Adult ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Tunisia |
| Abstract: | The prothrombin is the precursor of the serine protease thrombin, a key enzyme in homeostasis. Prothrombin G20210A polymorphism (rs1799963) was described as a moderate risk factor for venous thrombosis because this mutation is associated with prothrombin elevated levels which may lead to an imbalance between the procoagulant, anticoagulant, and fibrinolytic system. 20210A carriers have an increased risk of thrombosis. In this study, we proposed to determine the prevalence of 20210A prothrombin variant among Tunisian population, and to evaluate the potential relevance of this variant with myocardial infarction. This study included 1290 unrelated Tunisians (1007 male and 283 female) divided in two groups: Four hundred and eighty-seven MI patients (mean age: 52.64 ± 8.98 years) and 803 apparently healthy controls (mean age: 51 ± 8.99). The prothrombin G20210A polymorphism was carried out by polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis. The distribution of genotypes was in accordance with Hardy-Weinberg equilibrium (p > 0.05). A significant difference in genotype distribution and allele frequency was observed between patients and controls. Male patients with MI had a frequency of 97 % for GG genotype and 3 % for GA+AA genotypes. The control group had a frequency of 99 % for the GG genotype and 1 % for the GA+AA genotypes which is significantly lower than the frequency found in patients (p = 0.01). The same genotype frequencies were found in women (p = 0.032). The MI patient group showed a significantly higher frequency of 20210A allele compared to controls 0.02 versus 0.01 [OR = 3.60 (95 % CI = 1.29-10.53), p = 0.005] in men and 0.015 versus 0.068 [OR = 4.68 (95 % CI = 1.60-14.26), p = 0.001] in women. Our work showed a significant but not independent association between the G20210A polymorphism of the prothrombin gene and MI in the Tunisian population. |
| Contributed Indexing: | Keywords: Myocardial infarction; Polymorphism; Prothrombin |
| Substance Nomenclature: | 9001-26-7 (Prothrombin) |
| Entry Date(s): | Date Created: 20160617 Date Completed: 20170118 Latest Revision: 20221207 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10528-016-9744-y |
| PMID: | 27306359 |
| Database: | MEDLINE |
Journal Article