Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students.
| Title: | Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students. |
|---|---|
| Authors: | Lepeta K; Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.; Lourenco MV; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Schweitzer BC; Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Magdeburg, Germany.; Martino Adami PV; Laboratory of Amyloidosis and Neurodegeneration, Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina.; Banerjee P; Department of Biochemistry, Institute of Post Graduate Medical Education & Research, Kolkata, West Bengal, India.; Catuara-Solarz S; Systems Biology Program, Cellular and Systems Neurobiology, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; de La Fuente Revenga M; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, United States of America.; Guillem AM; Laboratorio de Neurotoxicología, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México D.F. 07000, Mexico.; Haidar M; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.; Ijomone OM; Department of Human Anatomy, Cross River University of Technology, Okuku Campus, Cross River, Nigeria.; Nadorp B; The Department of Biological Chemistry, The Edmond and Lily Safra Center for Brain Sciences, The Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem, Israel.; Qi L; Laboratory of Molecular Neuro-Oncology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, United States of America.; Perera ND; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.; Refsgaard LK; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Reid KM; Department of Pharmacology, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, UK.; Sabbar M; Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Sahoo A; Department of Biochemistry, Midnapore Medical College, West Bengal University of Health Sciences, West Bengal, India.; Schaefer N; Institute for Clinical Neurobiology, Julius-Maximilians-University of Wuerzburg, Wuerzburg, Germany.; Sheean RK; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.; Suska A; Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.; Verma R; Department of Neurosciences Uconn Health Center, Farmington, CT, United States of America.; Vicidomini C; CNR, Institute of Neuroscience, Milan, Italy.; Wright D; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.; Zhang XD; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.; Seidenbecher C; Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Magdeburg, Germany. seidenc@lin-magdeburg.de.; Center for Behavioral Brain Sciences (CBBS) Magdeburg, Magdeburg, Germany. seidenc@lin-magdeburg.de. |
| Source: | Journal of neurochemistry [J Neurochem] 2016 Sep; Vol. 138 (6), pp. 785-805. Date of Electronic Publication: 2016 Sep 08. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : Oxford, UK : Wiley on behalf of the International Society for Neurochemistry; Original Publication: New York : Raven Press |
| MeSH Terms: | Nervous System Diseases/*pathology ; Synapses/*pathology; Neurodegenerative Diseases/pathology ; Adult ; Child ; Humans |
| Abstract: | Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783.; (© 2016 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.) |
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| Contributed Indexing: | Keywords: Alzheimer disease; Down syndrome; autism; epilepsy; hyperekplexia; synapses |
| Entry Date(s): | Date Created: 20160623 Date Completed: 20170613 Latest Revision: 20220330 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5095804 |
| DOI: | 10.1111/jnc.13713 |
| PMID: | 27333343 |
| Database: | MEDLINE |
Journal Article; Review; Research Support, Non-U.S. Gov't