Analgesic effect of a single dose of betamethasone after ambulatory knee arthroscopy: a randomized controlled trial.
| Title: | Analgesic effect of a single dose of betamethasone after ambulatory knee arthroscopy: a randomized controlled trial. |
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| Authors: | Segelman J; Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, 118 81, Stockholm, Sweden. jerker.segelman@sodersjukhuset.se.; Pettersson HJ; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Svensén C; Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, 118 81, Stockholm, Sweden.; Divander MB; Section of Anaesthesiology and Intensive Care, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, 118 81, Stockholm, Sweden.; Barenius B; Section of Orthopaedic Surgery, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Segelman J; Department of Molecular Medicine and Surgery, Karolinska Institutet, Ersta Hospital, Stockholm, Sweden. |
| Source: | Journal of anesthesia [J Anesth] 2016 Oct; Vol. 30 (5), pp. 803-10. Date of Electronic Publication: 2016 Jul 01. |
| Publication Type: | Journal Article; Randomized Controlled Trial |
| Language: | English |
| Journal Info: | Publisher: Springer International for the Japan Society of Anesthesiology Country of Publication: Japan NLM ID: 8905667 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-8359 (Electronic) Linking ISSN: 09138668 NLM ISO Abbreviation: J Anesth Subsets: MEDLINE |
| Imprint Name(s): | Publication: Tokyo : Springer International for the Japan Society of Anesthesiology; Original Publication: [Tokyo] : Japan Society of Anesthesiology, [1987- |
| MeSH Terms: | Arthroscopy/*methods ; Betamethasone/*administration & dosage ; Glucocorticoids/*administration & dosage ; Postoperative Pain/*drug therapy; Analgesics/administration & dosage ; Knee Joint/surgery ; Postoperative Nausea and Vomiting/epidemiology ; Adult ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Pain Measurement |
| Abstract: | Purpose: Glucocorticoids are reported to improve postoperative analgesia. The purpose of the study was to investigate whether a preoperative, single dose of betamethasone could reduce pain after ambulatory arthroscopic knee surgery.; Methods: This was a randomized, double-blind, placebo-controlled trial including patients scheduled for knee arthroscopy. The intervention was an intravenous injection of betamethasone 8 mg or placebo. The primary outcome was pain day 1 evaluated by a verbal descriptor scale (VDS).; Results: In total, 74 patients (betamethasone = 34; placebo = 40) were randomized. One patient in each group was excluded from analysis. During activity day 1 following surgery, the proportion with no or minor pain was significantly (p = 0.030) higher in the betamethasone group (22 of 33; 67 %) compared with the placebo group (17 of 39; 44 %). At rest, the corresponding figures were 26 of 33 (79 %) for betamethasone and 24 of 39 (62 %) for placebo (p = 0.062). After 3 months of follow-up, no patient receiving betamethasone experienced adverse events while six receiving placebo did (postoperative nausea and vomiting in five and delayed wound healing in one).; Conclusions: An analgesic benefit was seen day 1 following surgery. This indicates that betamethasone has a place in ambulatory arthroscopic knee surgery.; Trial Registration: https://www.clinicaltrialsregister.eu/ (identifier 2009-014717-27). |
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| Contributed Indexing: | Keywords: Arthroscopy; Betamethasone; Pain; Randomized controlled trial |
| Substance Nomenclature: | 0 (Analgesics); 0 (Glucocorticoids); 9842X06Q6M (Betamethasone) |
| Entry Date(s): | Date Created: 20160703 Date Completed: 20170717 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s00540-016-2209-y |
| PMID: | 27370892 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial