Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men.
| Title: | Liver fat accumulation in response to overfeeding with a high-fat diet: a comparison between South Asian and Caucasian men. |
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| Authors: | Wulan SN; Department of Human Biology, Nutrition and Toxicology Research Institute (NUTRIM) - School for Nutrition Toxicology and Metabolism, Maastricht University Medical Center (MUMC+), Universiteitssingel 50, PO.Box 616, 6200MD Maastricht, The Netherlands ; Laboratory of Food Quality and Nutrition, Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Brawijaya University, Malang, East Java Indonesia.; Schrauwen-Hinderling VB; Department of Human Biology, Nutrition and Toxicology Research Institute (NUTRIM) - School for Nutrition Toxicology and Metabolism, Maastricht University Medical Center (MUMC+), Universiteitssingel 50, PO.Box 616, 6200MD Maastricht, The Netherlands ; Department of Radiology, Maastricht Academic Hospital, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.; Westerterp KR; Department of Human Biology, Nutrition and Toxicology Research Institute (NUTRIM) - School for Nutrition Toxicology and Metabolism, Maastricht University Medical Center (MUMC+), Universiteitssingel 50, PO.Box 616, 6200MD Maastricht, The Netherlands.; Plasqui G; Department of Human Biology, Nutrition and Toxicology Research Institute (NUTRIM) - School for Nutrition Toxicology and Metabolism, Maastricht University Medical Center (MUMC+), Universiteitssingel 50, PO.Box 616, 6200MD Maastricht, The Netherlands. |
| Source: | Nutrition & metabolism [Nutr Metab (Lond)] 2015 May 20; Vol. 12, pp. 18. Date of Electronic Publication: 2015 May 20 (Print Publication: 2015). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101231644 Publication Model: eCollection Cited Medium: Print ISSN: 1743-7075 (Print) Linking ISSN: 17437075 NLM ISO Abbreviation: Nutr Metab (Lond) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BioMed Central, 2004- |
| Abstract: | Background: South Asians were reported to have a higher liver fat content as compared to BMI-matched Caucasians. This study compared the increase in liver fat content in response to overfeeding with a high fat diet in South Asian and Caucasian men when matched for body fat percentage.; Methods: Ten South Asian men (BMI 18-29 kg/m(2)) and 10 Caucasian men (BMI 22-33 kg/m(2)), aged 20-40 y, matched for body fat percentage, were included. A weight maintenance diet was given for 3 days based on the individual energy requirement. Individual energy requirement of the subjects was calculated based on their body composition (measured by hydro densitometry and deuterium dilution) and activity counts (accelerometer). Liver fat content was measured before and after 4 days of overfeeding (50 % excess energy need) with a high fat diet (60 % energy from fat). Fat distribution was measured by anthropometry and an MRI scan of the abdomen while liver fat content using 1H-MRS.; Results: While having a similar body fat % (P = 0.58), South Asians had a lower BMI (P = 0.04) than Caucasians. Liver fat content at baseline did not differ between ethnicities (P = 0.48) and was associated with visceral fat area (P = 0.002, R(2) = 0.56) but not with ethnicity (P = 0.13). Overfeeding with a high fat diet significantly increased liver fat (P = 0.01) but the increase did not differ between ethnicities (P = 0.47). There was no difference in the total abdominal fat area (P = 0.37), subcutaneous abdominal fat area (P = 0.18) and visceral fat area (VAT, P = 0.32). However as a percentage of the total abdominal fat area, VAT was higher in South Asians (P = 0.003).; Conclusion: Despite a relatively higher percentage of visceral fat area, liver fat increased similarly in South Asian and Caucasian men in response to overfeeding with a high fat diet.; Trial Registration: The study was registered in the public trial registry www.ccmo.nl No. NL31217.068.10. |
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| Contributed Indexing: | Keywords: Body fat distribution; Liver fat content; Overfeeding; South Asian men |
| Entry Date(s): | Date Created: 20160714 Date Completed: 20160713 Latest Revision: 20201001 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC4940726 |
| DOI: | 10.1186/s12986-015-0015-4 |
| PMID: | 27408613 |
| Database: | MEDLINE |
Journal Article