Role of actin in shaping autophagosomes.
| Title: | Role of actin in shaping autophagosomes. |
|---|---|
| Authors: | Zientara-Rytter K; a Section of Molecular Biology, Division of Biological Sciences, University of California , San Diego, La Jolla , CA , USA.; Subramani S; a Section of Molecular Biology, Division of Biological Sciences, University of California , San Diego, La Jolla , CA , USA. |
| Source: | Autophagy [Autophagy] 2016 Dec; Vol. 12 (12), pp. 2512-2515. Date of Electronic Publication: 2016 Oct 10. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Language: | English |
| Journal Info: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Philadelphia, PA : Taylor & Francis; Original Publication: Georgetown, TX : Landes Bioscience, 2005- |
| MeSH Terms: | Actins/*metabolism ; Autophagosomes/*metabolism; Cell Membrane/metabolism ; Microtubule-Associated Proteins/metabolism ; Animals ; Humans ; Models, Biological |
| Abstract: | One of the main unanswered questions regarding the early steps of macroautophagy/autophagy is the mechanism of membrane-modeling events required for autophagosome formation. Three independent studies have recently revealed an actin cytoskeleton involvement in this process, providing significant details regarding the role of actin in nucleation events both inside and outside the phagophore membrane during its expansion and assembly. |
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| Grant Information: | R03 AI142388 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: CAPZ; JMY; WASL; WHAMM; actin; autophagosome shape; autophagy; nucleation-promoting factor |
| Substance Nomenclature: | 0 (Actins); 0 (Microtubule-Associated Proteins) |
| Entry Date(s): | Date Created: 20161011 Date Completed: 20171113 Latest Revision: 20250315 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5173263 |
| DOI: | 10.1080/15548627.2016.1236877 |
| PMID: | 27723370 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural