Internal exposure to neutron-activated 56Mn dioxide powder in Wistar rats: part 1: dosimetry.
| Title: | Internal exposure to neutron-activated 56Mn dioxide powder in Wistar rats: part 1: dosimetry. |
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| Authors: | Stepanenko V; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation. mrrc@mrrc.obninsk.ru.; Rakhypbekov T; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Otani K; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.; Endo S; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.; Satoh K; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.; Kawano N; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.; Shichijo K; Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan.; Nakashima M; Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan.; Takatsuji T; Nagasaki University, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan.; Sakaguchi A; University of Tsukuba, 1-1-1, Tsukuba-shi Tennodai, Ibaraki, 305-8571, Japan.; Kato H; University of Tsukuba, 1-1-1, Tsukuba-shi Tennodai, Ibaraki, 305-8571, Japan.; Onda Y; University of Tsukuba, 1-1-1, Tsukuba-shi Tennodai, Ibaraki, 305-8571, Japan.; Fujimoto N; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.; Toyoda S; Okayama University of Science, 1-1, Kitaku Ridai-cho, Kita-ku, Okayama, 700-0005, Japan.; Sato H; Ibaraki Prefectural University of Health Science, 4669-2, Ami-chyo Ami, Inashiki-gun, Ibaraki, Japan.; Dyussupov A; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Chaizhunusova N; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Sayakenov N; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Uzbekov D; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Saimova A; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Shabdarbaeva D; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Skakov M; National Nuclear Center of the Republic of Kazakhstan, Krasnoarmeyskaya Str., 2, Build 54 B, 071100, Kurchatov, Republic of Kazakhstan.; Vurim A; National Nuclear Center of the Republic of Kazakhstan, Krasnoarmeyskaya Str., 2, Build 54 B, 071100, Kurchatov, Republic of Kazakhstan.; Gnyrya V; National Nuclear Center of the Republic of Kazakhstan, Krasnoarmeyskaya Str., 2, Build 54 B, 071100, Kurchatov, Republic of Kazakhstan.; Azimkhanov A; National Nuclear Center of the Republic of Kazakhstan, Krasnoarmeyskaya Str., 2, Build 54 B, 071100, Kurchatov, Republic of Kazakhstan.; Kolbayenkov A; National Nuclear Center of the Republic of Kazakhstan, Krasnoarmeyskaya Str., 2, Build 54 B, 071100, Kurchatov, Republic of Kazakhstan.; Zhumadilov K; Eurasian National University named after L.N. Gumilyov, Munaipasova Str. 13, Astana, 010008, Republic of Kazakhstan.; Kairikhanova Y; Semey State Medical University, Kazakhstan, Abay Str., 103, Semey, 071400, Republic of Kazakhstan.; Kaprin A; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Galkin V; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Ivanov S; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Kolyzhenkov T; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Petukhov A; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Yaskova E; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Belukha I; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Khailov A; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Skvortsov V; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Ivannikov A; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Akhmedova U; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Bogacheva V; Medical Radiological Research Center (MRRC) named after A.F. Tsyb - National Medical Research Radiological Center of the Health Ministry of the Russian Federation, Koroliova Str. 4, Obninsk, Kaluga Region, 249036, Russian Federation.; Hoshi M; Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. |
| Source: | Radiation and environmental biophysics [Radiat Environ Biophys] 2017 Mar; Vol. 56 (1), pp. 47-54. Date of Electronic Publication: 2017 Feb 10. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0415677 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2099 (Electronic) Linking ISSN: 0301634X NLM ISO Abbreviation: Radiat Environ Biophys Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag. |
| MeSH Terms: | Neutrons* ; Radioisotopes*; Manganese Compounds/*chemistry ; Manganese Compounds/*metabolism ; Oxides/*chemistry ; Oxides/*metabolism; Animals ; Powders ; Radiation Dosage ; Radioactivity ; Radiometry ; Rats ; Rats, Wistar |
| Abstract: | There were two sources of ionizing irradiation after the atomic bombings of Hiroshima and Nagasaki: (1) initial gamma-neutron irradiation at the moment of detonation and (2) residual radioactivity. Residual radioactivity consisted of two components: radioactive fallout containing fission products, including radioactive fissile materials from nuclear device, and neutron-activated radioisotopes from materials on the ground. The dosimetry systems DS86 and DS02 were mainly devoted to the assessment of initial radiation exposure to neutrons and gamma rays, while only brief considerations were given for the estimation of doses caused by residual radiation exposure. Currently, estimation of internal exposure of atomic bomb survivors due to dispersed radioactivity and neutron-activated radioisotopes from materials on the ground is a matter of some interest, in Japan. The main neutron-activated radionuclides in soil dust were 24Na, 28Al, 31Si, 32P, 38Cl, 42K, 45Ca, 46Sc, 56Mn, 59Fe, 60Co, and 134Cs. The radionuclide 56Mn (T 1/2 = 2.58 h) is known as one of the dominant beta- and gamma emitters during the first few hours after neutron irradiation of soil and other materials on ground, dispersed in the form of dust after a nuclear explosion in the atmosphere. To investigate the peculiarities of biological effects of internal exposure to 56Mn in comparison with external gamma irradiation, a dedicated experiment with Wistar rats exposed to neutron-activated 56Mn dioxide powder was performed recently by Shichijo and coworkers. The dosimetry required for this experiment is described here. Assessment of internal radiation doses was performed on the basis of measured 56Mn activity in the organs and tissues of the rats and of absorbed fractions of internal exposure to photons and electrons calculated with the MCNP-4C Monte Carlo using a mathematical rat phantom. The first results of this international multicenter study show that the internal irradiation due to incorporated 56Mn powder is highly inhomogeneous, and that the most irradiated organs of the experimental animals are: large intestine, small intestine, stomach, and lungs. Accumulated absorbed organ doses were 1.65, 1.33, 0.24, 0.10 Gy for large intestine, small intestine, stomach, and lungs, respectively. Other organs were irradiated at lower dose levels. These results will be useful for interpretation of the biological effects of internal exposure of experimental rats to powdered 56Mn as observed by Shichijo and coworkers. |
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| Contributed Indexing: | Keywords: 56Mn; Experimental rats; Internal dosimetry; Monte Carlo simulation; Neutron activation; Radioactive dust |
| Substance Nomenclature: | 0 (Manganese Compounds); 0 (Oxides); 0 (Powders); 0 (Radioisotopes); TF219GU161 (manganese dioxide) |
| Entry Date(s): | Date Created: 20170212 Date Completed: 20170912 Latest Revision: 20181113 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s00411-016-0678-x |
| PMID: | 28188481 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't