[Platelet Metabolism in Clopidogrel Resistant and Sensitive Patients With Ischemic Heart Disease].
| Title: | [Platelet Metabolism in Clopidogrel Resistant and Sensitive Patients With Ischemic Heart Disease]. |
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| Authors: | Grinshtein IY; Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.; Scientific Research Institute of medical problems of the North Krasnoyarsk, Russia.; Savchenko AA; Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.; Scientific Research Institute of medical problems of the North Krasnoyarsk, Russia.; Grinshtein YI; Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.; Scientific Research Institute of medical problems of the North Krasnoyarsk, Russia.; Filonenko IV; Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.; Scientific Research Institute of medical problems of the North Krasnoyarsk, Russia.; Kosinova AA; Prof. V.F. Vojno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.; Scientific Research Institute of medical problems of the North Krasnoyarsk, Russia. |
| Source: | Kardiologiia [Kardiologiia] 2016 Oct; Vol. 56 (10), pp. 5-12. |
| Publication Type: | Journal Article |
| Language: | Russian |
| Journal Info: | Publisher: OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti Country of Publication: Russia (Federation) NLM ID: 0376351 Publication Model: Print Cited Medium: Print ISSN: 0022-9040 (Print) Linking ISSN: 00229040 NLM ISO Abbreviation: Kardiologiia Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Moskva : OOO Obshchestvo spet︠s︡ialistov po serdechnoĭ nedostatochnosti; Original Publication: Moskva. |
| MeSH Terms: | Blood Platelets/*metabolism ; Coronary Artery Disease/*blood ; Platelet Aggregation Inhibitors/*pharmacology ; Ticlopidine/*analogs & derivatives; Blood Platelets/drug effects ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/surgery ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Ticlopidine/pharmacology ; Ticlopidine/therapeutic use ; Aged ; Clopidogrel ; Coronary Artery Bypass ; Drug Resistance ; Humans ; Male ; Middle Aged ; Platelet Function Tests |
| Abstract: | Objective: to investigate relationship between activity of platelet nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) dependent dehydrogenases in patients with ischemic heart disease (IHD) after coronary artery bypass grafting (CABG) and their sensitivity to clopidogrel.; Material and Methods: We studied 51 male patients with chronic IHD before and after CABG. Control group comprised 35 healthy men. In IHD patients spontaneous and induced platelet aggregation was measured by aggregometry before CABG (in 2 weeks after cessation of antiplatelet drugs), after CABG during therapy with clopidogrel (75 mg/day), and in 6 months after surgery. Patients were classified as clopidogrel sensitive or resistant using cutoff of 50% inhibition of initial ADP (5 M) induced platelet aggregation after 2 weeks of treatment with clopidogrel. Activity of platelet NAD and NADP dependent dehydrogenases was measured by bioluminescent method.; Results: There were 41 clopidogrel sensitive and 10 clopidogrel resistant patients. Irrespective of sensitivity to clopidogrel platelet metabolism in IHD patients was characterized by reduced activity of anaerobic energetics, glutathione-dependent antioxidant system, reactions that transport products of lipid catabolism on glycolysis, and NADPH-dependent transfer of substrates from citric acid cycle to amino acid metabolism. Metabolic features of platelets characteristic of clopidogrel resistance were low activity of the key reaction of pentose phosphate cycle reflecting state of plastic metabolism, and substrate flow in the tricarbonic acid cycle - determinant of intensity of aerobic energy. Clopidogrel-sensitive patients had increased platelets NADP-malate dehydrogenase activity (the key reaction of lipid anabolism). |
| Contributed Indexing: | Keywords: NAD and NADP-dependent dehydrogenases; clopidogrel; ischemic heart disease; platelets; resistance |
| Substance Nomenclature: | 0 (Platelet Aggregation Inhibitors); A74586SNO7 (Clopidogrel); OM90ZUW7M1 (Ticlopidine) |
| Entry Date(s): | Date Created: 20170315 Date Completed: 20180725 Latest Revision: 20260505 |
| Update Code: | 20260505 |
| PMID: | 28290889 |
| Database: | MEDLINE |
Journal Article