Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.
| Title: | Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells. |
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| Authors: | Salazar TE; Genetics Institute, Gainesville, Florida, USA.; College of Medicine, Gainesville, Florida, USA.; Department of Ophthalmology, Indianapolis, Indiana, USA.; Richardson MR; Wells Center for Pediatric Research, Indianapolis, Indiana, USA.; Beli E; Department of Ophthalmology, Indianapolis, Indiana, USA.; Ripsch MS; Department of Anesthesia, Indianapolis, Indiana, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA.; George J; College of Medicine, Gainesville, Florida, USA.; Kim Y; Department of Anesthesia, Indianapolis, Indiana, USA.; Duan Y; Department of Ophthalmology, Indianapolis, Indiana, USA.; Moldovan L; Department of Ophthalmology, Indianapolis, Indiana, USA.; Yan Y; Genetics Institute, Gainesville, Florida, USA.; Bhatwadekar A; Department of Ophthalmology, Indianapolis, Indiana, USA.; Jadhav V; Department of Anesthesia, Indianapolis, Indiana, USA.; Smith JA; Department of Anesthesia, Indianapolis, Indiana, USA.; McGorray S; Department of Biostatistics, Gainesville, Florida, USA.; Bertone AL; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.; Traktuev DO; Krannert Institute of Cardiology, Indianapolis, Indiana, USA.; Indiana Center for Vascular Biology and Medicine, Indianapolis, Indiana, USA.; March KL; Krannert Institute of Cardiology, Indianapolis, Indiana, USA.; Indiana Center for Vascular Biology and Medicine, Indianapolis, Indiana, USA.; Colon-Perez LM; Department of Psychiatry, McKnight Brain Institute, Gainesville, Florida, USA.; Avin KG; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.; Sims E; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.; Mund JA; Wells Center for Pediatric Research, Indianapolis, Indiana, USA.; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.; Case J; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.; Scripps Clinic Medical Group, Scripps Center for Organ and Cell Transplantation, La Jolla, California, USA.; Deng X; Mainland Acupuncture Center, Gainesville, Florida, USA.; Kim MS; College of Veterinary Medicine, Chon Buk National University, Jeonju, South Korea.; McDavitt B; McDavitt Veterinary Clinic, Zionsville, Indiana, USA.; Boulton ME; Department of Ophthalmology, Indianapolis, Indiana, USA.; Thinschmidt J; Department of Pharmacology and Therapeutics, Gainesville, Florida, USA.; Li Calzi S; Department of Ophthalmology, Indianapolis, Indiana, USA.; Fitz SD; Department of Psychiatry, Indianapolis, Indiana, USA.; Fuchs RK; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.; Warden SJ; Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indianapolis, Indiana, USA.; McKinley T; Department of Orthopedic Surgery, Indianapolis, Indiana, USA.; Shekhar A; Department of Psychiatry, Indianapolis, Indiana, USA.; Febo M; Department of Psychiatry, McKnight Brain Institute, Gainesville, Florida, USA.; Johnson PL; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Chang LJ; Department of Molecular Genetics and Microbiology, Gainesville, Florida, USA.; School of Medicine, University of Electronic Science and Technology of China, Sichuan, China.; Gao Z; The Brown Foundation, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.; Kolonin MG; The Brown Foundation, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA.; Lai S; Department of Radiation Oncology, College of Medicine, Gainesville, Florida, USA.; Ma J; Department of Radiation Oncology, College of Medicine, Gainesville, Florida, USA.; Dong X; Department of Neuroscience, Center of Sensory Biology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; White FA; Department of Anesthesia, Indianapolis, Indiana, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, USA.; Xie H; College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.; Yoder MC; Wells Center for Pediatric Research, Indianapolis, Indiana, USA.; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana, USA.; Grant MB; Department of Ophthalmology, Indianapolis, Indiana, USA. |
| Source: | Stem cells (Dayton, Ohio) [Stem Cells] 2017 May; Vol. 35 (5), pp. 1303-1315. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9304532 Publication Model: Print Cited Medium: Internet ISSN: 1549-4918 (Electronic) Linking ISSN: 10665099 NLM ISO Abbreviation: Stem Cells Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2022- : Oxford : Oxford University Press; Original Publication: Dayton, OH : AlphaMed Press, c1993- |
| MeSH Terms: | Electroacupuncture*; Central Nervous System/*cytology ; Mesenchymal Stem Cells/*cytology; Achilles Tendon/pathology ; Adipocytes/cytology ; Adipose Tissue, Brown/cytology ; Adipose Tissue, White/cytology ; Antigens, CD/metabolism ; Forelimb/physiology ; Hindlimb/physiology ; Hyperalgesia/therapy ; Hypothalamus/cytology ; Interleukin-10/blood ; Macrophages/cytology ; Nerve Net/physiology ; Sensory Receptor Cells/metabolism ; Uncoupling Protein 1/metabolism ; Acupuncture Points ; Animals ; Humans ; Mice ; Rats ; Rupture |
| Abstract: | Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 and LI-11, and GV-14 and GV-20 (humans) and Bai-hui (rats) increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSCs) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue, whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation. EA-mediated SNS activation was further supported by browning of white adipose tissue in rats. EA treatment of rats undergoing partial rupture of the Achilles tendon resulted in reduced mechanical hyperalgesia, increased serum interleukin-10 levels and tendon remodeling, effects blocked in propranolol-treated rodents. To distinguish the afferent role of the peripheral nervous system, phosphoinositide-interacting regulator of transient receptor potential channels (Pirt)-GCaMP3 (genetically encoded calcium sensor) mice were treated with EA acupuncture points, ST-36 and LIV-3, and GV-14 and Bai-hui and resulted in a rapid activation of primary sensory neurons. EA activated sensory ganglia and SNS centers to mediate the release of MSC that can enhance tissue repair, increase anti-inflammatory cytokine production and provide pronounced analgesic relief. Stem Cells 2017;35:1303-1315.; (© 2017 AlphaMed Press.) |
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| Grant Information: | K08 DK110429 United States DK NIDDK NIH HHS; R01 HL109602 United States HL NHLBI NIH HHS; R01 EY012601 United States EY NEI NIH HHS; R01 EY023629 United States EY NEI NIH HHS; U54 DK106846 United States DK NIDDK NIH HHS; R01 EY025383 United States EY NEI NIH HHS; R01 HL110170 United States HL NHLBI NIH HHS; I01 BX002209 United States BX BLRD VA; R01 DK090730 United States DK NIDDK NIH HHS; R01 EY007739 United States EY NEI NIH HHS; R01 NS054791 United States NS NINDS NIH HHS; R25 GM109432 United States GM NIGMS NIH HHS; P30 CA082709 United States CA NCI NIH HHS; UL1 TR001427 United States TR NCATS NIH HHS; R01 DK100905 United States DK NIDDK NIH HHS |
| Contributed Indexing: | Keywords: Adult stem cells; Mesenchymal stem cells; Nervous system; Neurones |
| Substance Nomenclature: | 0 (Antigens, CD); 0 (Uncoupling Protein 1); 130068-27-8 (Interleukin-10) |
| Entry Date(s): | Date Created: 20170317 Date Completed: 20180122 Latest Revision: 20240610 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5530374 |
| DOI: | 10.1002/stem.2613 |
| PMID: | 28299842 |
| Database: | MEDLINE |
Journal Article