Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension.
| Title: | Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension. |
|---|---|
| Authors: | Swift AJ; 1 Department of Infection, Immunity and Cardiovascular Disease and.; 2 Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom.; Capener D; 1 Department of Infection, Immunity and Cardiovascular Disease and.; Johns C; 1 Department of Infection, Immunity and Cardiovascular Disease and.; Hamilton N; 3 Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital and.; Rothman A; 1 Department of Infection, Immunity and Cardiovascular Disease and.; 2 Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom.; Elliot C; 3 Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital and.; Condliffe R; 3 Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital and.; Charalampopoulos A; 3 Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital and.; Rajaram S; 4 Radiology Department, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom; and.; Lawrie A; 1 Department of Infection, Immunity and Cardiovascular Disease and.; 2 Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom.; Campbell MJ; 5 Scharr, Design, Trials & Statistics, Sheffield, United Kingdom.; Wild JM; 1 Department of Infection, Immunity and Cardiovascular Disease and.; 2 Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom.; Kiely DG; 1 Department of Infection, Immunity and Cardiovascular Disease and.; 2 Insigneo Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom.; 3 Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital and. |
| Source: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2017 Jul 15; Vol. 196 (2), pp. 228-239. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2000- : New York, NY : American Thoracic Society; Original Publication: New York, NY : American Lung Association, c1994- |
| MeSH Terms: | Magnetic Resonance Imaging*; Hypertension, Pulmonary/*diagnostic imaging; Hypertension, Pulmonary/physiopathology ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/physiopathology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Sensitivity and Specificity |
| Abstract: | Rationale: Prognostication is important when counseling patients and defining treatment strategies in pulmonary arterial hypertension (PAH).; Objectives: To determine the value of magnetic resonance imaging (MRI) metrics for prediction of mortality in PAH.; Methods: Consecutive patients with PAH undergoing MRI were identified from the ASPIRE (Assessing the Spectrum of Pulmonary Hypertension Identified at a Referral Centre) pulmonary hypertension registry.; Measurements and Main Results: During the follow-up period of 42 (range, 17-142) months 576 patients were studied and 221 (38%) died. A derivation cohort (n = 288; 115 deaths) and validation cohort (n = 288; 106 deaths) were identified. We used multivariate Cox regression and found two independent MRI predictors of death (P |
| Comments: | Comment in: Am J Respir Crit Care Med. 2017 Jul 15;196(2):129-131. doi: 10.1164/rccm.201704-0721ED.. (PMID: 28707971); Comment in: Am J Respir Crit Care Med. 2018 Mar 1;197(5):676-677. doi: 10.1164/rccm.201709-1842LE.. (PMID: 28961018); Comment in: Am J Respir Crit Care Med. 2018 Mar 1;197(5):675-676. doi: 10.1164/rccm.201707-1530LE.. (PMID: 28961026) |
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| Grant Information: | 205188/Z/16/Z United Kingdom WT_ Wellcome Trust; FS/13/48/30453 United Kingdom BHF_ British Heart Foundation; SP/14/6/31350 United Kingdom BHF_ British Heart Foundation; NIHR-RP-R3-12-027 United Kingdom DH_ Department of Health; MR/M008894/1 United Kingdom MRC_ Medical Research Council |
| Contributed Indexing: | Keywords: magnetic resonance imaging; prognosis; prognostic models; pulmonary arterial hypertension |
| Entry Date(s): | Date Created: 20170323 Date Completed: 20170731 Latest Revision: 20250530 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5519970 |
| DOI: | 10.1164/rccm.201611-2365OC |
| PMID: | 28328237 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't