Effect of investigational kisspeptin/metastin analog, TAK-683, on luteinizing hormone secretion at different stages of the luteal phase in goats.
| Title: | Effect of investigational kisspeptin/metastin analog, TAK-683, on luteinizing hormone secretion at different stages of the luteal phase in goats. |
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| Authors: | Rahayu LP; Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan.; Behiry ME; Visiting Research Scientist from Egypt, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; Endo N; Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan.; Tanaka T; Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.; United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan. |
| Source: | The Journal of reproduction and development [J Reprod Dev] 2017 Jun 21; Vol. 63 (3), pp. 221-226. Date of Electronic Publication: 2017 Mar 25. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Japanese Society of Animal Reproduction Country of Publication: Japan NLM ID: 9438792 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4400 (Electronic) Linking ISSN: 09168818 NLM ISO Abbreviation: J Reprod Dev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tokyo : Japanese Society of Animal Reproduction |
| MeSH Terms: | Luteal Phase*; Kisspeptins/*pharmacology ; Luteinizing Hormone/*metabolism; Animals ; Female ; Goats |
| Abstract: | This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an investigational metastin/kisspeptin analog, through treatment during different stages of the luteal phase in goats. Nine cycling Shiba goats (4.4 ± 2.3 years old) were assigned to early luteal phase (ELP, n = 4), mid-luteal phase (MLP, n = 4), and control (n = 5) groups. The ELP and MLP groups were administered 50 µg of TAK-683 intravenously on either day 5 or between days 7-14 after ovulation, respectively. The control group received vehicle between days 7-14 after ovulation. Blood samples were collected at 10-min (2-6 h), 2-h (6-24 h), and 24-h (24-96 h) intervals after treatment. Significant increases in plasma LH concentration were detected during the periods of 3 to 5 h and 2 to 5 h in the ELP and MLP groups, respectively. Estradiol concentrations continuously increased with the rise of basal LH secretion after TAK-683 treatment in two goats of the ELP group with a surge-like release of LH, but not in the goats without LH surge, i.e. the MLP and control group ones. Plasma progesterone concentration and the lengths of estrous cycle in all groups did not change significantly from the time before and after treatment. Present findings indicate that the responses of LH and ovarian steroids to treatment with TAK-683 depend on the stage of the luteal phase of the estrous cycle. We suggest that the stimulatory effects of TAK-683 on LH secretion are reduced in the process leading to the mid-luteal phase in cycling goats. |
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| Contributed Indexing: | Keywords: Goats; Luteal phase; Luteinizing hormone (LH) secretion; TAK-683 |
| Substance Nomenclature: | 0 (Kisspeptins); 0 (TAK-683); 9002-67-9 (Luteinizing Hormone) |
| Entry Date(s): | Date Created: 20170328 Date Completed: 20180518 Latest Revision: 20181202 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC5481624 |
| DOI: | 10.1262/jrd.2016-183 |
| PMID: | 28344192 |
| Database: | MEDLINE |
Journal Article